| 杨亚汝,许小云,张贵祥,李玉洁,赵京龙,姜露莹.兔VX2肝癌模型的建立及超声评价[J].中国医学影像技术,2003,19(12):1603~1605 |
| 兔VX2肝癌模型的建立及超声评价 |
| Establishment of Rabbit Model Bearing VX2 Liver Tumor and Ultrasound Evaluation |
| 投稿时间：2003-06-14 |
| DOI： |
| 中文关键词: 肝 VX2肿瘤 动物模型 兔 超声 |
| 英文关键词:tumor Animal model Rabbit Ultrasound |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨不同方法制作兔VX2移植性肝癌模型的特点,评价超声检查在监测VX2肝癌中的价值。方法 将VX2细胞滤液、VX2瘤株小块及VX2瘤株小块+明胶海绵分别注射或接种于28只新西兰大白兔的肝脏内,一周后不同时间行超声检查。结果 A组滤液注射法:平均成瘤时间约21天,肝的原位成瘤率为75％。B组包块埋植法:平均成瘤时间14天,肝的原位成瘤率为83％。C组包块埋植+明胶海绵法:平均成瘤时间14天,肝的原位成瘤率88％。三组成瘤率统计学无显著差异(χ2=1.118,P＞0.05)。肝脏内的移植瘤在超声上均表现为低回声伴声晕的肿块,彩色多普勒血流成像表现为周边血供丰富,中央血供稀少。结论 三种方法均能制成肝癌模型,超声检查是一种监测肝癌模型的有效手段。 |
| 英文摘要: |
| Objective To discuss three methods of making rabbit model bearing VX2 liver tumor and to evaluate the application of ultrasound in evaluating tumor model. Methods Twenty-eight New Zealand white rabbits were inoculated with cell suspension or a small piece of or a small piece with gelatin sponge of VX2 tumor in the left lobe of liver. Series of ultrasound scanning were performed in the experimental animals after 1 week of implantation or injection of VX2 tumor. Results The growth rate of neoplasia was 75% with a mean time of 21 days in group A and 83% with a mean time of 14 days in group B and 88% with a mean time of 14 days in group C separately. There was no difference in three groups (χ2=1.118, P>0.05). All the tumors are low echo companied with dark circle which are hypervascular showed by CDFI. Conclusion All three methods can be used in making rabbit model bearing VX2 liver tumor. US is useful in evaluating liver tumor. |
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