| 于继徐.TACE对肝癌细胞凋亡和增殖的影响[J].中国医学影像技术,2003,19(9): |
| TACE对肝癌细胞凋亡和增殖的影响 |
| The Effect of TACE on the Apoptosis and the Proliferation in Hepatocellular Carcinoma |
| 投稿时间：2003-01-03 |
| DOI： |
| 中文关键词: 癌,肝细胞 化学栓塞,治疗性 细胞凋亡 增殖细胞核抗原 经动脉化疗栓塞术 |
| 英文关键词:Carcinoma, hepatocellular Chemoembolization, therapeutic Apoptosis Proliferating cell nuclear antigen Transcatheter arterial chemoembolization |
| 基金项目:本课题为山东省教育厅资助课题(J99K58)。 |
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| 中文摘要: |
| 目的 探讨经动脉化疗栓塞术(TACE)对肝细胞癌细胞凋亡指数(AI)和细胞增殖指数(PCNA-LI)的影响,以及AI和PCNA-LI的相关性。方法 经病理证实的肝细胞癌病例63例,包括单纯手术组42例,TACE组21例。采用TUNEL法和免疫组织化学SP法分别检测各标本的AI和PCNA-LI。 结果 TACE组AI高于单纯手术组,PCNA-LI低于单纯手术组(P<0.01),AI和PCNA-LI呈高度负相关(P<0.01)。TACE组术后血清AFP值较术前下降(P<0.05),肿瘤缩小,坏死率增高(P<0.01)。结论 TACE可以明显增加HCC细胞凋亡率,降低细胞增殖率,从而促使肿瘤缩小,促进肿瘤坏死,达到治疗目的。 |
| 英文摘要: |
| Objective To discuss the effect of transcatheter arterial chemoembolization (TACE) on the apotosis index (AI) and the PCNA-Labeling index (PCNA-LI) in hepatocellular carcinoma (HCC), and the correlation between AI and PCNA-LI. Methods Sixty-three HCC specimens verified by histopathology were studied, including 42 cases treated with surgical resection alone, and 21 cases undergoing TACE. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and immuno-histochemistry method were used to observe the apoptosis and PCNA. Results HCCs treated with TACE had a significantly higher AI and a lower PCNA-LI than those treated with surgical resection alone (P<0.01). AI was highly inversely related to PCNA-LI (P<0.01). Serum AFP of HCCs treated with TACE decreased (P<0.05). HCCs treated with TACE contracted and had more necrosis (P<0.01). Conclusion TACE could increase AI, decrease PCNA-LI, result a decreased tumor size and more tumor necrose, and thus increase the survival rate of patients of HCC. |
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