| 向慧娟,邓又斌,常青,黎春蕾,毕小军,杨好意,王林.超声心动图评价川崎病后冠状动脉内皮功能[J].中国医学影像技术,2003,19(9): |
| 超声心动图评价川崎病后冠状动脉内皮功能 |
| Evaluation of Coronary Endothelial Function after Kawasaki Disease Using Echocardiography |
| 投稿时间：2003-04-27 |
| DOI： |
| 中文关键词: 内皮功能 冠状动脉 冷加压试验 川崎病 超声心动图 |
| 英文关键词:Endothelial function Coronary artery Gamma globulin Kawasaki disease Echocardiography |
| 基金项目:国家自然科学基金资助课题(30270560)。 |
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| 中文摘要: |
| 目的 应用超声心动图评价川崎病后冠状动脉内皮功能,明确川崎病急性期丙种球蛋白的应用是否对晚期冠状动脉内皮功能异常有作用。方法 应用超声心动图仪测量39例有川崎病病史患者及17例健康对照者冷加压试验前后及舌下含服硝酸甘油后的冠状动脉左主干内径,计算其内径百分变化率。结果 冷加压试验诱导的冠状动脉左主干内径百分变化率在川崎病组明显低于对照组,分别为1.0%±4.7%及 11.1%±3.8%,P<0.0001。舌下含服硝酸甘油所诱导的冠状动脉内径百分变化率两组间无显著性差异(P>0.05)。川崎病急性病程中是否早期应用丙种球蛋白者冷加压前后冠状动脉左主干内径百分变化率无显著性差异(分别为1.0%±4.5%及0.4%±6.4%,P>0.05)。结论 冷加压试验诱导的冠状动脉左主干内径百分变化率在有川崎病病史者较健康儿童减低,提示川崎病后存在冠状动脉内皮功能的异常。川崎病急性期大剂量丙种球蛋白的早期治疗不能干预冠状动脉内皮功能。 |
| 英文摘要: |
| Objective Echocardiography was used to evaluate coronary endothelial function after Kawasaki disease (KD) and to determine whether the use of gamma globulin therapy in the acute stage of KD affects the later endothelial dysfunction. Methods The left main trunk diameter in 39 patients with a history of KD and 17 matched healthy subjects before and after cold pressor test and after sublingual nitroglycerin administration was measured and the percent change in the left main coronary artery diameter was calculated. Results The percent change in the left main coronary artery diameter induced by the cold pressor test in the patients with a history of KD (1.0%±4.7%) was significantly less than that in the control group (11.1%±3.8%, P<0.0001). No significant difference could be found in the percent change in the left main coronary artery diameter induced by sublingual administration of nitroglycerin between the controls and the patients(P>0.05). There was no significant difference in percent change in diameter of the left main coronary artery induced by the cold pressor test between the patients who received gamma globulin (1.0%±4.5%) and those who did not(0.4%±6.4%, P>0.05). Conclusion The decreased percent change in the diameter of the left main coronary artery induced by the cold pressor test in patients with a history of KD compared with the healthy children indicates that coronary endothelial dysfunction exists after KD. Coronary endothelial function is not influenced by early treatment with high-dose gamma globulin in the acute stage of KD. |
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