| 赵海涛,陆军,张卓立,孙立军,魏光全,韩月东,常英娟,张劲松,宦怡.31P 磁共振波谱对心肌梗死能量代谢变化的评价[J].中国医学影像技术,2003,19(9):1128~1130 |
| 31P 磁共振波谱对心肌梗死能量代谢变化的评价 |
| Evaluation of the Changes in Myocardial Infarction |
| 投稿时间：2003-05-13 |
| DOI： |
| 中文关键词: 磁共振波谱 存活心肌 能量代谢 |
| 英文关键词:Magnetic resonance spectroscopy Viable myocardium Energy metabolism |
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| 中文摘要: |
| 目的 利用31P 磁共振波谱评价心肌梗死后心肌能量代谢的变化,区分存活心肌与梗死心肌。方法 对10例证实为前壁心梗的患者,CABG(coronary artery bypass grafting)治疗术前(2~8天)及术后(4~6个月)行电影MRI和31P MRS检查,检测前壁心肌PCr、ATP、Pi,并计算PCr/γ-ATP、PCr-SNR及γ-ATP-SNR,确定前壁心肌节段心功能恢复情况,观察梗死前壁节段心肌31P MRS检测高能磷酸盐变化与心肌活力的关系。对照组10例志愿者参加研究。结果 前壁心肌梗死后存活心肌(7例)31P MRS显示PCr-SNR和γ-ATP-SNR与健康志愿者比较无显著差异(P>0.05)。MRI检测无活力心肌3例,31P MRS基本未测出PCr峰且 γ-ATP-SNR与健康志愿者比较显著减低(P<0.05)。结论 31P 磁共振波谱可用于评价心肌梗死后心肌能量代谢的变化,是非侵入性心肌高能磷酸盐监测的有利工具。 |
| 英文摘要: |
| Objective To investigate the change in myocardial infarction by 31P MR spectroscopy, and to distinguish the viable myocardium from the infarct myocardium. Methods Ten patients with anterior myocardial infarction performed cine-MRI and 31P MRS (using 2D-CSI technique) before and after coronary artery bypass grafting, and adenosine triphosphate (ATP), phosphocreatine (PCr), and inorganic phosphate (Pi) of the anterior myocardium were measured, and PCr/γ-ATP, PCr-SNR, and γ-ATP-SNR were calculated. The relationship between the changes of high energy phosphates measured by 31P MRS and the viability of infarct myocardium was observed. Results The 31P MRS of the viable myocardium showed that PCr-SNR and γ-ATP-SNR had no significant difference compared to 31P MRS of normal myocardium of healthy volunteers (P>0.05). PCr peak of the non-viable anterior myocardium could not be detected, and γ-ATP-SNR significantly reduced compared with that of normal myocardium (P<0.05). Conclusion 31P MRS can be used to evaluate the changes of myocardial energy metabolism after infarction. It is a noninvasive tool in assessing the human myocardial energy metabolism. |
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