| 熊树华,王智彪,李发琪,田耘博,胡凯,龚晓波,马平.高强度聚焦超声肝脏生物学焦域及超声监控[J].中国医学影像技术,2003,19(9):1113~1115 |
| 高强度聚焦超声肝脏生物学焦域及超声监控 |
| Research of Hepatic Biological Focal Region of High-Intensity Focused Ultrasound and Its Real-Time Monitoring with Ultrasonography in vivo |
| 投稿时间：2003-04-20 |
| DOI： |
| 中文关键词: 高强度聚焦超声 生物学焦域 肝脏 在体 深度 时间 超声显像检查 |
| 英文关键词:High intensity focused ultrasound Biological focal region Liver Invivo Depth Time Ultrasonography |
| 基金项目:本课题受国家"九五"重点科技攻关项目(96-905-02-01)和国家自然科学基金委重点项目(39630340)资助。 |
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| 中文摘要: |
| 目的 探讨在相同声强作用下,高强度聚焦超声经体外辐照肝脏形成的生物学焦域体积大小与辐照深度和辐照时间的关系。同时探讨超声显像法实时监控生物学焦域的图像变化规律。方法 采用重庆医科大学医学超声工程研究所自主研制的JC-A型HIFU肿瘤治疗系统(1MHz,5500W·cm-2),对18只山羊的肝脏组织进行体外定点脉冲辐照,辐照深度为距皮肤3cm和4cm,辐照时间为5s、10s、15s和20s。辐照过程中系列测量靶区超声灰度和强回声区面积的变化。辐照后3~5天处死动物,剖腹观察并测量所形成的肝脏HIFU生物学焦域的体积。结果 肝脏经体外HIFU辐照后即刻,靶区内出现明显的回声增强并随观测时间延长而逐渐降低。强回声区面积随辐照时间增加而增大。辐照时间为5s、10s、15s和20s,辐照深度为3cm时,形成的生物学焦域体积分别为(85±28.0)mm3、(274±55.0)mm3、(410±90.0)mm3和(694±131.0)mm3;而辐照深度为4cm时,肝脏HIFU生物学焦域体积则分别为:(63±7.0)mm3、(167±25.0)mm3、(273±56.0)mm3和(472±104.0)mm3。结论 在相同辐照声强作用下,肝脏HIFU生物学焦域体积随辐照时间的增加而增加,随辐照深度的增加而减小。 |
| 英文摘要: |
| Objective To explore the formation of hepatic HIFU biological focal region and its real-time monitoring with ultrasonography in vivo. Methods The hepatic tissue under 30mm or 40mm depth of skin of 18 goats was radiated extracorporeally by HIFU (1MHz, 5500W·cm-2) with times of 5s, 10s, 15s or 20s. The changed value of gray scale and maximal cross sectional area of hyperechoic regions were recorded on the schedule. After 3-5 days of HIFU radiation,all the animals were killed and BFR were measured on autopsy. Results Immediately after HIFU irradiation, the targeted zones appeared hyperecho. The value of gray scale in the targeted zone decreased gradually. Their maximal cross sectional areas of hyperechoic region augmented with increase of radiating time. Under 30mm depth of skin and radiating times of 5s, 10s, 15s or 20s, the volumes of hepatic BFR was (85±28.0)mm3, (274±55.0)mm3, (410±90.0)mm3 and (694±131.0)mm3, respectively. Under 40mm depth of skin and radiating times of 5s, 10s, 15s or 20s, the volumes of hepatic BFR was (63±7.0)mm3, (167±25.0)mm3, (273 ±56.0)mm3 and (472±104.0)mm3, respectively. Conclusion With the same amount of acoustic intensity and radiating time, the volumes of biological focal regions decreased with the increased depth of radiation.With the given HIFU intensity and irradiating HIFU intensity and irradiating depth unchange,the volumes increased with the augmentation in time. After HIFU irradiation,the targeted zones in the liver appeared hyperechoic. The ultrasonography could real-time monitor the HIFU biological focal regions. |
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