| 高建华,张迎光,彭志康,张茂根,郑建辉.经动脉超选择热化疗栓塞治疗肝癌的临床应用[J].中国医学影像技术,2003,19(4):454~456 |
| 经动脉超选择热化疗栓塞治疗肝癌的临床应用 |
| Clinical Application of Superselective Transcatheter Arterial Heated Chemoembolization for Hepatocellular Carcinoma |
| 投稿时间：2002-12-18 |
| DOI： |
| 中文关键词: 肝癌 化疗栓塞 热疗 介入放射学 |
| 英文关键词:Liver neoplasm Chemoembolization Thermotherapy Interventional radiology |
| 基金项目:广东省江门市科委科技攻关项目(20018108)。 |
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| 中文摘要: |
| 目的 研究经动脉超选择热化疗栓塞治疗肝癌的方法和疗效.方法 69例肝癌患者随机分为两组,实验组39例,行经动脉超选择热化疗栓塞,将5-FU、卡铂及丝裂霉素与生理盐水或碘油混合,加热至55~65℃后经微导管注入肝癌滋养动脉。对照组30例,行经动脉超选择化疗栓塞,温度控制在20℃。术后记录体温、肝功能变化。观察有无并发症出现。术后每月复查甲胎蛋白(AFP)及CT,独立盲法评价碘油沉积情况及肿瘤大小变化,并根据病情变化制定后续的治疗方案,统计肝癌患者生存率。结果 实验组生存率:0.5年、1年、1.5年、2年、3年、4年分别为,100% 、97%、90% 、79% 、62% 、38%,与对照组相比有显著差异(P<0.05);肝功能变化与对照组无差异(P>0.05);实验组毒副作用与对照组相比无显著性差异。结论 经动脉超选择热化疗栓塞治疗肝癌是较方便、简单、安全的方法,能显著提高疗效,延长患者生存期。 |
| 英文摘要: |
| Purpose To investigate the effectiveness and methodology of superselective transcatheter arterial heated chemoembolization for hepatocellular carcinoma. Methods Sixty-nine cases of hepatocellular carcinoma were randomly divided into two groups.Thirty-nine cases were treated with superselective transcatheter arterial heated chemoembolization,while 30 cases were treated without heat.In the experimental group,all the 5-fluorouracilum,carboplatinum and mitomycinum C were heated to 55~65℃ with either lipiodol or normal saline before injected into segmental hepatic artery or tumor feeding artery.While in control group,the temperature was controlled at 20℃.Postoperative body temperature and liver function change were recorded.CT and AFP were examined each month.CT film was read independently,according to which follow-up treatment was given.Survival rate was recorded. Results In the experimental group,0.5,1,1.5,2,3,4 year survival rate were 100%,97%,90%,79%,62%,38%respectively,significantly higher than those in control group (P<0.05).No significant difference was found between two groups according to the changes of liver fuction and poisonous side effect. Conclusion Superselective transcatheter arterial heated chemoembolization is a simple,convenient and safe method for treatment of hepatocellular carcinoma,which is more effective in improving the survival rate. |
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