| 李林法,刘小焦,吴福生,朱阳军.99Tcm-MIBI乳腺显像在鉴别乳腺肿瘤良恶性 及腋窝淋巴结转移的临床应用研究[J].中国医学影像技术,2003,19(4):426~428 |
| 99Tcm-MIBI乳腺显像在鉴别乳腺肿瘤良恶性 及腋窝淋巴结转移的临床应用研究 |
| Investigation of 99Tcm-MIBI Imaging in Differential Diagnosis of Breast Masses and in Detection of Metastatic Axillary Lymph Node |
| 投稿时间：2002-10-25 |
| DOI： |
| 中文关键词: 乳腺肿瘤 淋巴转移 腋 腈类 放射性核素显像 |
| 英文关键词:Breast neoplasm Lymphatic metastasis Axilla Nitriles Radionuclide imaging |
| 基金项目: |
| 作者 | 单位 | | 李林法 | Department of Nuclear Medicine,the First Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310003,China | | 刘小焦 | 外科, | | 吴福生 | 肿瘤科,浙江杭州 310003 | | 朱阳军 | Department of Nuclear Medicine,the First Affiliated Hospital,Zhejiang University College of Medicine,Hangzhou 310003,China |
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| 中文摘要: |
| 目的 评价99Tcm-甲氧基异丁基异腈(MIBI)显像在判断乳腺肿块良、恶性及诊断腋窝转移淋巴结中的价值。方法 采用自制乳腺显像装置,经病变乳腺对侧肘静脉注射99Tcm-MIBI 555~740MBq后15min即行早期乳腺显像,分别采集正前位、左、右侧位像,采集计数1000k,1.5h后按上述条件作延迟显像。结果 34例乳腺肿块患者,99Tcm-MIBI核素显像阳性22例,阴性12例;24例乳腺癌患者99Tcm-MIBI核素显像阳性20例、阴性4例;10例良性病变中99Tcm-MIBI核素显像阴性8例、阳性2例;99Tcm-MIBI核素显像诊断乳腺癌的灵敏度为83.3%,特异性80.0%,准确性为82.4%,阳性预测值90.9%,阴性预测值66.7%;99Tcm-MIBI核素显像对腋窝淋巴结转移检出的灵敏度为80.0%,特异性为92.9%,阳性预测值88.9%,阴性预测值为86.7%,准确性为87.5%。结论 99Tcm-MIBI显像对触及乳腺肿块的患者能提供非常有价值的临床信息,能较好地鉴别诊断乳腺肿块的良、恶性。 |
| 英文摘要: |
| Objective To evaluate prospectively the sensitivity and specificity of 99Tcm-MIBI scintimammography in the differential diagnosis of breast masses and the metastasis axillary lymph node in breast cancer. Methods The 555~750MBq 99Tcm-MIBI was injected into an antecubital vein contralateral to the palpable breast lesion.The early and delay images were acquired at 15min and 1.5h after injection of the tracer.The imaging was performed using special designed imaging device made by ourselves.Three planar views,right and left lateral and anterior views including both axillae were obtained.The acquisition counts should be reached 1000k. Results Of the 34 cases,22 patients' 99Tcm-MIBI images were positive,and 12 images negitive.There were 20 true-positive,4 false-negitive in 24 malignants imaging.And 2 false-positive,8 true-negitive in 10 benigns.The sensitivity of 99Tcm-MIBI images in diagnosis of breast cancer was 83.3%,and the specificity was 80.0%,the positive and the negative predictive values were 90.9% and 66.7%,the accuracy was 82.4%.The sensitivity of scintimammography in detecting metastatic axillary lymph node was 80.0%,and the specificity was 92.9%,the positive and the negative predictive values were 88.9% and 86.7%,the acuracy was 87.5%. Conclusion 99Tcm-MIBI images provides clinically valuable information on patients with palpable breast masses.99Tcm-MIBI scintigraphy of breast can well differential between malignant and benign masses,but the sensitivity for lesions was related to the tumor size in some degree. |
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