| 刘晋,徐克,张曦彤,黄亘,张斌.[J].中国医学影像技术,2003,19(2):129~132 |
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| Experimental Contrast Study of Homemade Noncovered and Covered Polyurethane Stent Used in Arterial System |
| 投稿时间：2002-08-12 |
| DOI： |
| 中文关键词: 动脉 支架 动物,实验 放射学 |
| 英文关键词:Artery Stents Grafts and prostheses Animal,laboratory Radiology |
| 基金项目: |
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| 摘要点击次数: 2480 |
| 全文下载次数: 872 |
| 中文摘要: |
| 目的 探讨自制覆膜与非覆膜Z型不锈钢支架在动脉系统中应用的可行性。 方法 本实验共用9条健康杂种犬,按观察时间随机分为3组(3条/组)。应用介入放射学方法分别将自制Z型医用316L不锈钢支架(简称:Z-SSS支架9枚和被覆聚氨酯(polyurethane)膜的Z型不锈钢支架(简称:PU-SSS支架11枚置入犬的腹主动脉。实验动物分别于支架置入后2周、4周、12周行血管造影复查。处死实验动物,行组织学检查并进行统计学分析。 结果 9枚Z-SSS和10枚PU-SSS成功置入靶血管。Z-SSS和PU-SSS的管腔开通率分别为:100%和27.27%,两者具有显著的统计学差异(P=0.001)。支架置入4周时,两种支架表面内皮化基本完成。PU-SSS引起的局部血栓形成、炎性反应和平滑肌细胞增生明显。2周、4周、12周时,两种支架新生内膜厚度分别为(359.23±50.15)μm、(440.87±58.38)μm、(581.28±121.25)μm和(178.49±14.67)μm、(1202.79±421.05)μm、(1466.06±463.19)μm,两者具有显著差异(P<0.01)。4周时,平滑肌细胞增殖细胞核抗原(PCNA)阳性细胞率分别为:(46.07±14.73)%和 (85.23±18.25)%,两者具有显著的差异(P<0.01)。扫描电镜:12周时支架表面内皮细胞成熟。置入12周的支架金属丝表面光洁,未见腐蚀现象。 结论 ①Z-SSS具有良好的机械特性、理化稳定性、抗凝血性和生物相容性,是一种较理想的动脉支架。②PU-SSS目前尚不适合于临床应用。 |
| 英文摘要: |
| Objective To study the feasibility of two kinds of homemade stent used in arterial system and to spread their clinical application. Methods Nine healthy hybrid canines were included in our study. Twenty prostheses,nine Z-type stainless steel stent (Z-SSS) and eleven Z-type stainless steel stent covered polyurethane (PU-SSS) were placed in canines' abdominal aorta. Following-up angiography was performed at 2 weeks,4 weeks and 12 weeks respectively after placement to observe the shape of vascular lumen and blood flow of collateral vessel. All animals were sacrificed according to grouping time. Prostheses were removed for histopathological examination. Measurement data was analyzed by t test. Enumeration data was analyzed by χ2 test. Results All except one stent were placed successfully in target vessels. The patency rates of Z-SSS and PU-SSS were 100% and 27.27%,respectively,with significant statistical difference (P=0.001). Two weeks,4 weeks and 12 weeks after the stent placement neointimal thicknesses of Z-SSS and PU-SSS were (359.23±50.15)μm,(440.87±58.38)μm,(581.28±121.25)μm and (178.49±14.67)μm,(1202.79±421.05)μm,(1466.06±463.19)μm,respectively,with significant statistical difference (P<0.01). Positive cell rate of proliferating cell nuclear antigen (PCNA) of SMC of both stents was (46.07±14.73)% and (85.23±18.25)%,respectively,at 4 weeks after placement,with significantly statistical difference (t=6.535,P<0.01). Endothelialization of both stents reached about 100% at 4 weeks after placement. Scanning electron microscopic examination indicated that endothelium on the surface of stents became mature at 12 weeks. Surface erosion of stainless stents struts was not found. Conclusion ①Z-SSS compared with PU-SSS has better mechanical behavior,physiochemical stability,anticoagulative capability and biocompatibility. It was an ideal intraarterial stent. ②PU-SSS is not fit for clinical application at present. |
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