| 蒋桔泉,曹林生,朱向明,聂绍平,曾秋棠,刘小青,卢晓芳.[J].中国医学影像技术,2003,19(1):1~3 |
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| Experimental Study of Effects of Transmyocardial Revascularization with KTP Laser on Myocardial Viability |
| 投稿时间：2002-05-11 |
| DOI： |
| 中文关键词: 心肌血运重建术 激光 存活心肌 |
| 英文关键词:Myocardial revascularization Laser Viable myocardium |
| 基金项目:本课题由华中科技大学激光技术国家重点实验室资助(200017)。 |
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| 中文摘要: |
| 目的 研究KTP激光心肌血运重建术(TMLR)对梗死局部心肌存活性的影响。方法 家犬12只,随机分为TMLR组和对照组,每组6只,结扎左前降支中段,造成急性心肌梗死犬模型,TMLR组在梗死区以KTP激光行TMLR。术后动物饲养2~3个月,采用多巴酚丁胺负荷超声心动图,检测心肌的存活性。结果 负荷超声心动图检查发现,TMLR组给予5μg／(kg·min)多巴酚丁胺后室壁收缩增厚率、室壁运动幅度和室壁运动速度均有不同程度的改善,但当多巴酚丁胺剂量增大到10μg／(kg·min),前壁的室壁收缩增厚率、室壁运动幅度和室壁运动速度反而又减低;而对照组给予多巴酚丁胺5μg／(kg·min)和10μg／(kg·min)后,室壁收缩增厚率、室壁运动幅度和室壁运动速度进行性减低。结论 KTP激光TMLR后梗死局部部分心肌保持存活。 |
| 英文摘要: |
| Objective To study the effects of transmyocardial revascularization with frequency-double Nd:YAG (KTP) laser on myocardial viability. Methods Left thoracotomy was performed in 12 adult mongrel dogs.The medius of the left anterior descending artery (LAD) was ligated to creat the acute myocardial infarction model.TMLR was performed with KTP laser in the acute infarcted LAD zone in TMLR group (n=6),and without any treating in control group (n=6).Myocardial viability was assessed by dobutamine stress echocardiography on 2-3 months after treatment. Results After 2-3 months,the regional functional parameters of the left ventricle increased in TMLR group during the infusion of dobutamine in 5μg／(kg·min),but decreased in 10μg／(kg·min),while the regional functional parameters of the left ventricle decreased gradually in control group during the infusion of dobutamine. Conclusion The viable myocardium can be detected with dobutamine stress echocardiography in the old infarcted zone of TMLR group. |
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