| 成官迅,张雪林,刘伊丽.急性心肌梗塞后危险区与梗塞区的识别[J].中国医学影像技术,2002,18(11):1098~1099 |
| 急性心肌梗塞后危险区与梗塞区的识别 |
| Distinguishment of the Risk and Infarcted Regions after Acute Myocardial Infarction |
| 投稿时间：2002-05-16 |
| DOI： |
| 中文关键词: 急性心肌梗塞 染色 MRI |
| 英文关键词:Acute myocardial infarction Stain Magnetic resonance imaging |
| 基金项目:广东省医学科学研究基金(基金编号 A2000390)。 |
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| 中文摘要: |
| 目的
探讨急性心肌缺血损伤后危险区与梗塞区的识别方法。方法 成年健康家
兔8只分别制作阻塞性心肌梗塞和缺血再灌注心肌梗塞模型,伊文思蓝和TTC
染色分别确定缺血区和梗塞区,染色前行MRI检查,放射微球(99m
Tc-MAA)测量心肌血流量作为标准对照,光镜和电镜检查验证染色结果。结果
伊文思蓝染色正常心肌呈蓝色,危险心肌和梗塞心肌染色阴性,TTC染色正常心肌
和危险心肌呈砖红色,梗塞心肌染色阴性,染色确定的病变部位与MRI完全一致。危险和梗
塞心肌血流量较正常心肌显著减少,病理损伤程度较正常心肌明显严重。结论 [
HTSS]伊文思蓝和TTC染色是动物实验中确定危险与梗塞心肌的可靠方法。 |
| 英文摘要: |
| Objective
To study the methods of disti
nguishing risk and infarcted regions after acute myocardial infarction (AMI).
Methods Eight rabbits were given ligation of left an
teri
or descending branch to make pathologic models of AMI. Risk and infarcted regio
ns were defined as Even's blue and 2,3,5 triphenyltetrazolium chloride (TTC) neg
ative regions respectively. MRI examination was performed before staining. Myo
cardial blood flow (MBF) was measured with radioactive microspheres( 99m Tc
-MAA). Light and electroscopy examination was used to demonstrate the staining
results. Results The normal myocardium was stained blue by Ev
en's
blue, but the risk and infarcted myocardium was negative. The risk and normal regions were stained brick red by TTC, but the infarcted regions was negat
ive. The diseased area detected by staining was the same as what detected by MR
I. The MBF in risk and infarcted region was reduced significantly than in norma
l region. The pathologic injury degree in risk and infarcted region was more se
vere than in normal region. Conclusion Even's blue and TTC s
taining were useful methods to distinguish risk and infarcted myocardium in anim
al experiments. |
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