| 陈伟,张绍祥,丁仕义,任建敏,杨旭,谢兵,张永克.磁共振单克隆抗体免疫靶向对比剂McAb-PMP的制备[J].中国医学影像技术,2002,18(9):942~944 |
| 磁共振单克隆抗体免疫靶向对比剂McAb-PMP的制备 |
| Preparation of the MRI Immunological Target Contrast Agent of PEG-Magnetite Particles Coated with CL-3 Monoclonal Antibody |
| 投稿时间：2001-11-29 |
| DOI： |
| 中文关键词: 磁共振 单克隆抗体 聚乙二醇 磁性微粒 |
| 英文关键词: MRI Monoclonal antibody Polyoxyethyleneglycol Magnetite particles |
| 基金项目: |
|
| 摘要点击次数: 2137 |
| 全文下载次数: 1017 |
| 中文摘要: |
| 目的 探讨磁共振单克隆抗体靶向对比剂的制备方法。 方法 以葡聚糖为载体,采用氧化法制备靶向磁性微粒。 结果 制备的磁性纳米微粒与单抗相比保持了较高的结合活性和免疫活性。 结论 合成CEA单克隆抗体标记磁性微粒,保证了结合活性免疫活性,为活体动物实验奠定了基础。 |
| 英文摘要: |
| Objective To evaluate the preparation of the MRI target contrast agent of PEG-magnetite particles coated with CL-3 monoclonal antibody. Methods Regarding dextran as carriers, the target magnetite particle was prepared by the periodate procedure. Results A nanometer of magnetite particles coated with CL-3 monoclonal antibody has a higher combination activation and immune activation compared with unbound McAb. Conclusion The target contrast agent of PEG-magnetite particle coated with CEA monoclonal antibody, guarantee to combine the immune activation of activation, has established the foundation for animal's experiment of living body. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
