| 王荣福,胡怀湘,范岩,付占立,张春丽,赵光宇,王彦福,林景辉.18F-FDG分子符合探测成像在肿瘤诊断中的临床价值[J].中国医学影像技术,2002,18(7):631~633 |
| 18F-FDG分子符合探测成像在肿瘤诊断中的临床价值 |
| Clinical Value of Molecular Coincidence Detection with 18F-FDG in the Diagnosis of Tumor |
| 投稿时间：2001-11-26 |
| DOI： |
| 中文关键词: 分子符合探测(MCD) 氟化脱氧葡萄糖(18F-FDG) 显像 肿瘤 |
| 英文关键词:Molecular coincidence detection (MCD) F-18-FDG Imaging Tumor |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨18F-FDG分子符合探测(MCD)肿瘤代谢显像应用和评价其临床价值。方法 对经组织学证实的44例原发性肿瘤、18例转移性肿瘤和10例肺部良性病变进行氟化脱氧葡萄糖(18F-FDG)MCD显像,将显像与组织学结果进行比较分析。结果 62例肿瘤患者中,59例FDG影像示单个或多处呈不同程度异常FDG浓聚灶,3例未见异常FDG浓聚灶。10例肺部良性病变FDG影像中, 3例肺部可见异常摄取增高,7例未见异常FDG浓聚影。本组研究的敏感度95.2%,特异性70%,阳性预测值95.5%,阴性预测值70%,诊断准确率92.1%。结论 FDG MCD/AC显像对肿瘤良恶性鉴别、分期和分级、疗效预测和预后判断具有一定优势。 |
| 英文摘要: |
| Purpose To validate the application of 2--fluoro-2-deoxy-D-glucose (18F-FDG) molecular coincidence detection (MCD) in tumor metabolism imaging and evaluate its clinical value. Methods Forty-four primary cancer, 18 recurrent cancer and 10 patients with lung benign lesions histopathologically determined were studied using 18F-FDG MCD imaging. The findings from FDG-MCD/AC imaging and histological diagnosis were analyzed. Results 18F-FDG imaging results in 59 of 62 patients with cancer showed one or more marked abnormally increasing uptake of FDG, 3 cases false negative. In 10 patients with lung benign lesions, 18F-FDG images of 7 cases showed no abnormal FDG accumulation, and 3 cases false positive. In this study, the sensitivity was 95.2%, the specificity was 70%, with positive predictive value of 95.5% and negative predictive value of 70%, and the diagnostic accuracy was 92.1%. Conclusion 18F-FDG MCD/AC imaging appeared to be useful in differentially diagnosing malignant from benign lesion, tumor staging and grading, predicting therapeutic efficacy and prognosis. |
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