| 段云友,王文,吕发勤,曹铁生,张龙方,贾化平.超声造影剂对兔肾VX2肿瘤血流显像影响的实验研究[J].中国医学影像技术,2002,18(7):613~615 |
| 超声造影剂对兔肾VX2肿瘤血流显像影响的实验研究 |
| Experimental Investigation of Contrast-Enhancement Effect on Ultrasonography Image of Rabbit Renal VX2 Tumor |
| 投稿时间：2002-03-12 |
| DOI： |
| 中文关键词: 肾肿瘤 超声造影 二次谐波技术 |
| 英文关键词: Renal tumor Contrast ultrasonography Second harmonic imaging |
| 基金项目:陕西省科学基金资助 (2001SM47)。 |
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| 中文摘要: |
| 目的 探讨超声造影剂对兔肾VX2肿瘤血流显像的影响。方法 采用超声引导下经皮组织块推注法建立22只兔肾VX2肿瘤模型,经兔耳缘静脉注射利声显200mg/ml,应用二次谐波技术和视频密度定量技术观测肿瘤与肾皮质灰阶、能量及频谱在造影前后的变化。结果 造影后肿瘤与肾皮质的灰阶差值由(1.04±12.49)dB/cm2增加到(11.77±15.17)dB/cm2,能量面积比(BFAR)差值由(12.84±4.61)%增加到(25.73±7.12)%,测得的瘤内血流速度由(22.01±8.16)cm/s增加到(29.50±8.73)cm/s,多普勒频谱视频密度由(117.89±49.74) dB/cm2增加到(142.43±51.31)dB/cm2, P值均小于0.01。结论 超声造影能显著提高兔肾VX2肿瘤图像的显示效果,明显增加多普勒血流信号强度。 |
| 英文摘要: |
| Purpose To explore the effect of contrast-enhancement on ultrasonography image of rabbit renal VX2 tumor. Methods There were twenty-two rabbit models in which left kidneys were implanted VX2 tumor. Levovist microbubbles were injected through ear vein at the dose of 200mg/ml. The second harmonic imaging and video-density quantitative determination were applied during the observation on the changes of tumor and renal cortex before and after Contrast-enhancement. Results Before and after Contrast-enhancement, the gray-scale balance between kidney cortex and tumor rised from (1.04±12.49)dB/cm2 to (11.77±15.17)dB/cm2, the BFAR from (12.84±4.61)% to (25.73±7.12)%, the velocity observed of intra-tumor blood flow from (22.01±8.16)cm/s to (29.50±8.73)cm/s, the video-density quantitative determination of Doppler spectrum from (117.89±49.74)dB/cm2 to (142.43±51.31)dB/cm2. Conclusion Contrast-enhancement can enhance manifest effect of rabbit renal VX2 tumor significantly, increase the intensity of Doppler flow signal. |
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