| 薛雁山,许建英,纪智.阻塞性肺气肿定量CT与肺功能检查相关性的实验研究[J].中国医学影像技术,2002,18(5):406~408 |
| 阻塞性肺气肿定量CT与肺功能检查相关性的实验研究 |
| Experimental Study on Correlation of Quantitative CT with Pulmonary Functional Tests in Obstructive Pulmonary Emphysema |
| 投稿时间：2001-11-13 |
| DOI： |
| 中文关键词: 肺气肿 HRCT 动物 实验 |
| 英文关键词:Pulmonary emphysema HRCT Animals Laboratory |
| 基金项目:本课题受山西省自然科学基金资助(20001070)。 |
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| 中文摘要: |
| 目的 通过实验研究探讨阻塞性肺气肿HRCT密度定量与肺功能检查间的相关性。方法 随机将45只大白鼠中的30只制成COPD模型,15只作为对照组。对实验动物做CT全肺扫描,测量两肺上、中和下三区的平均密度值。统计分析这些测量值与肺功能检查结果。结果 实验组动物的CT肺密度改变与PEF、IP Slope的变化有着较密切的相关性,r值分别为0.82和0.87,P值均<0.01。结论 阻塞性肺气肿HRCT密度定量能间接的反映阻塞性肺气肿的呼气阻力和呼吸肌力的变化。 |
| 英文摘要: |
| Objective To investigate the correlation of quantitative CT with pulmonary functional tests (PFTs) in obstructive pulmonary emphysema (OPE) by experimental study.Methods Forty-five rats were divided into two groups at random:experimental group in 30 rats were used as OPE models by expose them to 250ppm SO2 and 15 rats were used as control group. Experimental animals were examined by HRCT scanning and PFTs for the lungs.The mean attenuations as ROI were measured in upper, middle and lower regions of the lungs.The Results were statistically analyzed.Results Mean lung attenuations in OPE group were correlated well with PEF and IP slope of PFTs (r=0.82, 0.87; P<0.01).Conclusion Quantitative HRCT can reflect indirectly the changes of PEF and IP slope of PFTs in OPE. |
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