| 张燕燕,张俊波,王学斌,赵荣生,杨丽,张松林,王新,张卫方,唐志刚.新型脑显像剂 99TcmN(CHDTC)2的兔血药 清除动力学及猴脑显像初步研究[J].中国医学影像技术,2002,18(4):305~306 |
| 新型脑显像剂 99TcmN(CHDTC)2的兔血药 清除动力学及猴脑显像初步研究 |
| Research on Rabbit Pharmacokinetics and Monkey Brian Imaging of Novel Potential Cerebral Imaging Agent 99TcmN(CHDTC)2 |
| 投稿时间：2002-01-05 |
| DOI： |
| 中文关键词: 放射性核素 脑显像剂 动物 99TcmN(CHDTC)2 |
| 英文关键词:Radionuclide Brain imaging gent Animals 99TcmN(CHDTC)2 |
| 基金项目: |
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| 摘要点击次数: 2396 |
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| 中文摘要: |
| 目的 对一种新型脑显像剂 99TcmN(CHDTC)2进行临床前兔血药清除动力学、猴脑显像研究,以观其有无进一步临床研究的价值。方法 将用配体交换法制备的 99TcmN(CHDTC)2进行兔血药清除动力学、猴脑显像研究。结果 将放化纯大于90%的 99TcmN(CHDTC)2给兔静脉注射后其清除半衰期=8.70h;清除率=529.5ml/h。猴脑血流显像提示,注药后颅内放射性逐渐升高,至1h行脑SPECT显像,脑灰白质显像基本清楚。提示显像剂可进入血脑屏障,并在脑实质有较好滞留。结论 99TcmN(CHDTC)2是一种有潜力的新型脑显像剂,值得进行临床研究。 |
| 英文摘要: |
| Objective To study a novel potential cerebral imaging agent 99 TcmN(CHDTC)2 that would decide the value of further clinical research. Methods With prepared the complex and investigated the preclinical pharmacology in animals, kinetics of blood clearance in rabbits, cerebral imaging in a monkey were studied. Results Radiochemical purity of 99TcmN(CHDTC)2 was over 90%. Kinetics of blood clearance in the rabbits showed T1/2 (β)=8.70h; Cl=529.5ml/h. Cerebral blood flow imaging of the monkey showed that blood flow was rise slowly and up to peak at one hour. SPECT showed that cerebral perfusion imaging of the monkey was clear. The Results demonstrated that the agent could cross blood brain protective screen and accumulated as well as had a good retention at brain. Conclusion 99TcmN(CHDTC)2 is good potential cerebral imaging agent and there is value for further clinical research. |
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