| 唐杰,罗渝昆,张彦,吕晓川,李俊来,徐建宏,苏莉.含氟碳气体的表面活性剂类声学造影剂的体外实验[J].中国医学影像技术,2002,18(2):99~101 |
| 含氟碳气体的表面活性剂类声学造影剂的体外实验 |
| Ultrasound Contrast Agent of Surfactant Fluorocarbon-Filled in Vitro |
| 投稿时间：2001-09-23 |
| DOI： |
| 中文关键词: 超声 表面活性剂 造影剂 |
| 英文关键词:Ultrasound Surfactant Contrast agent |
| 基金项目:本课题受军队医药卫生科研基金资助(00J02)。 |
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| 中文摘要: |
| 目的 研究含氟碳气体的表面活性剂类声学造影剂的基本特性。方法 将具有表面活性作用的司班-80和吐温-80按一定的体积比配制,加入6%低分子右旋糖酐溶液至10ml,并将混合液充分搅拌;用声振仪振荡混合液40s,同时从注射器的底部匀速注入10ml全氟丙烷气体。光镜400倍下动态观察微气泡的浓度和直径,并运用体外循环系统观察不同剂量的彩色多普勒信号增强效果。结果 造影剂中微气泡的峰值浓度为3.8×109/ml,其中90%微气泡直径≤4.5μm。体外模拟循环系统的能量多普勒信号增强持续时间随剂量增加而增加。结论 表面活性剂类声学造影剂的微气泡直径小、浓度高,且具有价格低廉、制作简单和明显增强多普勒信号的特点,值得进一步深入研究。 |
| 英文摘要: |
| Objective The basic characteristics of ultrasound contrast agent of surfactant fluorocarbon-filled were studied. Methods Six percent dextrose was put in the mixture consisted of span-80 and tween-80 of the surfactant in proportion up to 10ml. Then it was sonicated for 40 seconds by sonicator, meanwhile in which 10ml perfluoropropane gas was injected. The concentration and size of the microbubbles was measured on a ×400 field of microscope. The effect of color Doppler signal were measured in extracorporeal circulative system after different dosage of contrast agent was injected. Results The peak concentration of contrast agent microbubble was 3.8×109/ml,90% size of microbubble ≤4.5μm. The persistence of color Doppler signals in extracorporeal circulative system increased with increasing the dosage. Conclusion The characteristics of surfactant contrast agent are small size, high concentration, cheap price, simple manufacture and obvious enhancement of Doppler signal. It would be researched further. |
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