| 梁宇霆,靳二虎,马大庆,张艺,付亚琴,高永庆.菲立磁增强MRI在肝脏局灶性病变诊断中的应用[J].中国医学影像技术,2001,17(6):556~558 |
| 菲立磁增强MRI在肝脏局灶性病变诊断中的应用 |
| Ferumoxides-Enhanced MR Imaging for Diagnosis of Focal Liver Lesions |
| 投稿时间：2001-03-15 |
| DOI： |
| 中文关键词: 菲立磁 肝脏局灶性病变 磁共振成像 造影增强 造影剂 |
| 英文关键词:Ferumoxides MRI Focal hepatic lesions Contrast enhancement Contrast media |
| 基金项目: |
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| 中文摘要: |
| 目的 评价菲立磁的安全性及在肝脏局灶性病变的检出及鉴别诊断中的作用。方法 30例经B超或CT发现肝内局限性病灶的患者进行菲立磁增强(0.05ml/kg,静脉滴入)前后MRI扫描。结果 所有患者增强后无生命体征改变,也未出现严重不良反应。恶性病例16例,增强前发现病灶28个,增强后48个,多发现20个,均为转移灶。89.6%的病灶增强后信号无降低,10.4%略降低。良性14例,多数良性病变(10/12,囊肿除外)信号可见不同程度减低。结论 菲立磁是一种安全、有效的肝脏阴性造影剂,对肝脏局灶性病变的良恶性鉴别有一定作用,能明显提高肝脏转移瘤的检出率。 |
| 英文摘要: |
| Objective To assess the safety and diagnostic efficacy of ferumoxides for depiction and differentiation of focal hepatic lesions on MRI. Methods 30 patients with focal hepatic lesions detected by USG or CT were included. MR images were obtained before and after intravenous infusion of ferumoxides(0.05ml/kg). Results There was no change in life signs after intravenous infusion of ferumoxides and no severe adverse reactions occurred in all patients. 28 lesions were detected on unenhanced images in 16 patients with malignant diseases, but 48 lesions on enhanced images. All of the additional 20 lesions were metastases. For malignant lesions, 89.6% presented no signal intensity loss, 10.4% moderate loss. Most of benign lesions (10/12, except cysts) presented signal intensity loss. Conclusion Ferumoxides is a safe and efficacious liver negative contrast agent. It may help to differentiate focal hepatic malignant lesions from benign lesions and improve the detection of liver metastases. |
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