| 贾建军,卢文甫,王鲁宁,汤洪川,尹岭.Pick病的诊断[J].中国医学影像技术,2001,17(4):318~320 |
| Pick病的诊断 |
| Diagnosis of Pick Disease |
| 投稿时间：2000-12-24 |
| DOI： |
| 中文关键词: Pick病 阿尔茨海默病 磁共振成像 正电子发射型计算机断层扫描 |
| 英文关键词:Pick disease Alzheimer disease Magnetic resonance imaging Positron emission tomography |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨Pick病(Pick disease)诊断的正确性。方法 分析2例临床上曾诊断为阿尔茨海默病(Alzheimer disease,AD),经核磁共振成像(MRI)检查证实的Pick病,其中1例经正电子发射型计算机断层扫描(PET)得到进一步证实。结果 Pick病与AD比较有如下特点:①特殊的语言方式及语言改变;②临床上以缓慢进展的性格改变及社会活动能力衰退为主,而记忆力、理解判断力、计算力障碍等出现相对较晚;③病程中有不同程度的Klüver-Bucy综合征表现;④脑MRI检查提示:额和(或)颞叶萎缩,颞极为著;⑤PET检查提示:双侧额、颞叶代谢减低,颞极明显。结论 根据Pick病临床表现及神经影像学特征,在排除AD及其它脑变性病的基础上,生前诊断Pick病是可能的。 |
| 英文摘要: |
| Objective To explore the definite diagnosis of pick disease. Methods Two cases of the pick disease diagnosised by clinical and MRI findings,one of them certified by PET.The patients had been diagnosised as Alzheimer disease(AD) before. Results There are the following features on pick disease as compared with AD:①The special type of speech and speech disorder;②The slowly progressive change of character and involution of social action emerged earlier in clinical and the disturbance of memory,comprehension and calculation emerged later;③Klüver-Bucy syndrome can be found in the course of the illness;④MRI showed:the atrophy of frontal-temporal lobe is obviously,especially on temporal pole;⑤Frontal-temporal lobe deficits on PET,especially on temporal pole. Conclusion The antemortem diagnosis of pick disease might be possible on the detailed basis of clinical manifestations, MRI and PET features, but other neurodegeneration disorders such as AD should be ruled out. |
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