| 华琦,邢绣荣,刘荣坤,何士大.氯沙坦、福辛普利及硝苯地平控释剂对高血压病患者 心脏结构、血流及功能作用之比较[J].中国医学影像技术,2001,17(2):161~163 |
| 氯沙坦、福辛普利及硝苯地平控释剂对高血压病患者 心脏结构、血流及功能作用之比较 |
| Comparison the Effects of Losartan , Fosinopril and Nifedipine GITS on Cardiac Structure and Functions in Patients with Essential Hypertension |
| 投稿时间：2000-12-18 |
| DOI： |
| 中文关键词: 高血压病 抗高血压药物 超声心动图 |
| 英文关键词:Essential hypertension Antihypertensive drugs Echocardiography |
| 基金项目:本科题受北京市科委课题资金资助(954023400)。 |
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| 中文摘要: |
| 目的 探讨氯沙坦、福辛普利和硝苯地平控释剂对高血压病患者心脏结构、血流及功能的影响,并进行比较。方法 87例轻中度高血压病患者随机分为3组,分别应用氯沙坦50mg/d(L组,30例) 、福辛普利10mg/d(F组,28例) 和硝苯地平控释剂30mg/d(N组,29例), 应用超声心动图(UCG),观察比较治疗前、治疗4周末及16周末诊所血压(CBP),心脏功能及左室心肌肥厚的逆转情况。结果 高血压病各组不良反应发生率分别为L组18.2%、F组39.4%、N组43.8%。治疗4周后CBP均有显著性降低,三组间无显著性差异,以硝苯地平控释剂组作用显著。16周末各组总有效率均达85%以上。4周末各组左室舒张功能均显著改善(P<0.05~0.001)。16周末各组左室肥厚逆转,以福辛普利与氯沙坦组作用显著(P<0.05)。结论 氯沙坦、福辛普利和硝苯地平控释剂均能有效持续地降低血压,改善高血压病早期的左室舒张功能损害。 |
| 英文摘要: |
| Purpose This study was aimed at investigating and contrasting the effects of Losartan, Fosinopril and Nifedipine GITS on cardiac structure and function in patients with essential hypertension (EH). Methods Eighty-seven patients with mild to moderate EH were randomly divided into three groups and were treated with Nifedipine GITS 30mg/d (n=29), Fosinopril 10mg/d (n=28) or Losartan 50mg/d (n=30) separately. Cardiac structure and function were measured with echocardiography before and after treatments of 4 and 16 weeks. Results The antihypertensive effects of three medicines had no statistical differences. Left ventricular diastolic function was improved at the end of 4 weeks (P<0.05~0.001). Left ventricular hypertrophy was regressed after 16 weeks treatment. The regression in F group was the largest and that in N group the smallest (P<0.05). Conclusion Three antihypertensive drugs all can significantly and safely decrease blood pressure, had strong effects on reversing ventricular hypertrophy, improve left ventricular diastolic function in early stage of hypertension. |
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