| 解恒革,程流泉,王鲁宁,蔡幼铨.轻度认知损伤患者海马杏仁核体积的MRI测量及临床随访研究[J].中国医学影像技术,2001,17(2):136~138 |
| 轻度认知损伤患者海马杏仁核体积的MRI测量及临床随访研究 |
| MRI-based Hippocampus and Amygdala Volumes in Mild Cognitive Impairment and Follow-up Study |
| 投稿时间：2000-08-24 |
| DOI： |
| 中文关键词: Alzheimer病 轻度认知损伤 MRI 海马 |
| 英文关键词:Alzheimer disease Mild cognitive impairment Magnetic resonance imaging Hippocampus |
| 基金项目:本研究受军队"九五"课题资助(98M139)和国家卫生部"九五"攻关课题资助。 |
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| 中文摘要: |
| 目的 探讨轻度认知损伤(MCI)患者海马、杏仁核萎缩在Alzheimer病(AD)发病中的作用。 方法 MCI组11例,AD组15例,正常老年人14例。GE 1.5T MR机,3D-FSPGR序列采样,冠状位,层厚1.3mm, 层数60,计算机三维重建并进行杏仁核海马体积测量,经标准化校正后进行比较,随访MCI患者进展为AD的情况。 结果 AD组海马杏仁核体积萎缩25％(P<0.05),MCI组萎缩5%~13%(P>0.05)。27.3%的MCI患者经1年随访进展为AD。 结论 伴海马、杏仁核萎缩的MCI患者更易于进展为AD。 |
| 英文摘要: |
| Objective To investigate the prediction of Alzheimer disease (AD) with MRI-based hippocampus and amygdala volumes in mild cognitive impairment(MCI). Methods 15 patients with AD, 11 with MCI and 14 normal elderly were examined by GE 1.5T MR machine using 3D-FSPGR sequence, 1.3mm slice thickness, 60 slices. The 3-dimensional reconstruction of hippocampus and amygdala was performed and measured on the Sunwork Station. The normalized volumes were analyzed, and one-year follow up study was performed in MCI patients. Results The AD patients had significantly smaller volumes of hippocampus and amygdala (-25%, P<0.05) compared to controls. The reduction of MCI in hippocampus and amygdala was mild(-5% to -13%, P>0.05). After one year follow-up, 27.3% in MCI met the criteria of AD. Conclusion Hippocampus and amygdala atrophy of MCI may be a predictor of developing AD. |
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