| 赵永生,赵峰,杨淑琴,杨海山.急性脑梗塞的动物实验及临床应用研究[J].中国医学影像技术,2001,17(2):125~127 |
| 急性脑梗塞的动物实验及临床应用研究 |
| Experiment Study in Animal and Clinical Application of Acute Cerebral Infarction |
| 投稿时间：2000-06-12 |
| DOI： |
| 中文关键词: 动物脑梗塞模型 急性脑血栓 介入溶栓治疗 DSA |
| 英文关键词:Animal model of acute cerebral infarction Acute cerebral thrombosis Local intra-arterial thrombolysis DSA |
| 基金项目:本课题为吉林省卫生厅科研课题(94239)。 |
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| 中文摘要: |
| 目的 通过建立脑梗塞动物模型,为介入溶栓治疗提供可靠依据。方法 对10只杂种犬进行常温和加温到50℃后自体血凝块注入致急性脑梗塞形成,经导管脑动脉灌注溶栓,观察血管狭窄、阻塞和再通的情况。结果 常温自体血凝块组,1~4h血管再通率为91%。6~12 h溶栓占89%,12~24h溶栓为76%,总复通率占86%。加温至50℃组,1~4h溶栓血管再通率为31.5%。6~12 h溶栓占20%,12~24h溶栓为5%,总复通率53.6%。结论 常温自体血凝块组溶栓后血管再通率高。6h 之内溶栓速度快,溶栓时间与溶栓疗效呈正相关。 |
| 英文摘要: |
| Purpose To provide information about local intra-arterial thrombolysis by establish a animal model of cerebral infarction. Methods 10 dogs were randomly divided into two groups(group A and B,n=5 for each),group A and B were infused in self-blood clot(no-heat and heat to 50℃)respectively after selective arterio-cerebral catheterization to formal acute cerebral infarction, and local intra-arterial thrombolysis was treated before and after thrombolysis to observe the station of vessal,stenosis、occulusion and recanalization. Results In group A,after local intra-arterial thrombolysis at 1~4、6~12、12~24 hours, the rate of recanalization were 91%、89%、76% respectively,the total rate was 86%;In group B,the rate of recanalization were 31.5%、20%、5% respectively at same time,the total rate was 53.6%.Conclusion The rate of recanalization in group A is better than group B,and the effective of local intra-arterial cerebral thrombolysis in 6 hours is better .Positive correlation was found between local intra-arterial thrombolysis time and effective. |
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