| 宾建平,ElizabethLe,RobertAPelberg,刘伊丽,查道刚,SanjivKaul.双嘧达莫负荷超声心动图探测冠状动脉狭窄的病理生理基础[J].中国医学影像技术,2001,17(2):122~124 |
| 双嘧达莫负荷超声心动图探测冠状动脉狭窄的病理生理基础 |
| The Physiopathologic Basis of Dipyridamole Stress Echocardiography in Detecting Coronary Stenosis |
| 投稿时间：2000-07-03 |
| DOI： |
| 中文关键词: 超声心动描记术 冠脉动脉疾病 双嘧达莫 |
| 英文关键词:Echocardiography Coronary artery disease Dipyridamole |
| 基金项目:本课题系在Dr Kaul实验室完成,受美国卫生部基金部分资助(R01-HL48890)和国家自然基金部分资助(39900058)。 |
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| 中文摘要: |
| 目的 探讨双嘧达莫负荷超声评价冠状动脉狭窄的病理生理基础。 方法 双嘧达莫负荷超声评价慢性冠脉狭窄犬的室壁增厚率(%WT),放射性微球定量心肌血流量(MBF)。 结果 负荷状态,MBF储备＜2的心肌节段%WT 减小;2≤ MBF储备＜3的节段%WT 无明显变化;而MBF储备≥3的节段%WT反而增加。 结论 狭窄冠脉MBF储备的异常程度可能是双嘧达莫负荷超声评价冠脉狭窄的主要病理生理基础。 |
| 英文摘要: |
| Objective To evaluate the physiopathologic basis of dipyridamole stress echocardiography in detecting coronary stenosis. Methods Fifteen dogs were studied 7~10 days after placement of ameriod constrictors around proximal LAD and LCX. MBF with radiolabeled microspheres and %WT with 2-D echocardiography was measured at rest, following 0.56mg/kg of dipyridamole. Results As compared with control, the %WT in the segments with MBF reserve ＜2 was decreased but the %WT in the segments with 2＜MBF reserve ≤3 was not different after dipyridamole. The %WT, however, was increased in segments with MBF reserve 33 after dipyridamole. Conculsion The level of the abnormal MBF reserve in stenosed coronary artery may be the mainly physiopathologic basis of dipyridamole stress echocardiography in detecting coronary stenosis. |
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