| 陈伟,巫北海,丁仕仪,梁智勇,张绍祥.实验性肝细胞癌MR成像与铜含量的关系研究[J].中国医学影像技术,2001,17(1):18~20 |
| 实验性肝细胞癌MR成像与铜含量的关系研究 |
| MR Imaging of Hepatocellular Carcinoma in Rats: Correlation of Metal Iron Content and Signal Intensity |
| 投稿时间：2000-08-04 |
| DOI： |
| 中文关键词: 肝细胞癌 铜含量 磁共振成像 |
| 英文关键词:Hepatocellular carcinoma Content of copper MR imaging |
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| 中文摘要: |
| 目的 初步阐明在MRI的常规SE序列,铜含量对肝细胞癌T1WI信号的影响。方法 用0.2％DEN(Sigma产品)灌喂Wistar大鼠(n=80),诱癌成功行常规SE序列T1WI、T2WI,对照组(n=20)不灌喂DEN,余同实验组。扫描后处死动物取肝组织与肝癌组织作HE染色,并测定组织内水、铜含量。结果 肝癌组织与癌周肝组织含水量无显著差异,肝癌组织内铜含量高于癌周肝组织,在呈高信号的肝组织内铜含量明显高于呈其它信号强度类型的肝组织。结论 水的含量不是影响肝癌MR表现的主要因素,肝癌内铜的蓄积对在SE T1WI呈高信号起作用。 |
| 英文摘要: |
| Purpose To investigate the relationship between the metal copper content of hepatocellular carcinoma (HCCJ) and the signal pattern on MR images. Methods Wistar rats (n=80) were examined on MR SE T1- weighted and T2-weighted after success of experimental hepatocellular carcinoma induced by 0.2％ diethylnitrosamine. After MR examination, rats were killed and the tissues of HCCs identified by pathological examined, the quantities of water and copper determined. Results There have no significant difference between HCCs and hepatic parenchyma of water content, the content of copper HCCs average high than surrounding parenchyma. Conclusion The water content is not primary factor HCCs MR appearance , copper accumulation might be a cause of high-intensity pattern on SE T1-weighted images of HCCs. |
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