| 李槐,刘德忠,陈雁,吴洁清,于涛,郝晓宁,李志芳,周纯武.中心型非小细胞肺癌术前支气管动脉灌注化疗疗效分析[J].中国医学影像技术,2000,16(11):933~935 |
| 中心型非小细胞肺癌术前支气管动脉灌注化疗疗效分析 |
| Short-term Results of Preoperative Bronchial Arterial Infusion in Central Non-small Cell Lung Cancer |
| 投稿时间：2000-07-26 |
| DOI： |
| 中文关键词: 非小细胞肺癌 支气管动脉灌注化疗 新辅助化疗 |
| 英文关键词:Non-small cell lung cancer Bronchial arterial infusion Neoadjuvant chemotherapy |
| 基金项目:本课题受国家“九五”攻关资助项目(962907203203) 。 |
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| 中文摘要: |
| 目的评价非小细胞肺癌(NSCLC) 术前支气管动脉灌注化疗(BAI) 近期疗效。方法经影像学判断手
术切除难度较大,或不能手术切除的中心型NSCLC 患者20 例行前瞻性术前BAI。BAI 后行手术切除。结果BAI
治疗前后TNM 分类改变5 例,其中N 下降1 例,5 例均有T 改变;临床分期下降2 例。PR 8 例,缓解率为40 % ,其
中鳞癌6 例,腺癌2 例;NC 12 例,其中腺癌1 例,其余为鳞癌。BAI 前后肺不张改善的9/ 12 例(75 %) ;与周围组织
关系密切或受侵改善的6/ 15 例(37.5 %) ;纵隔淋巴结肿大缩小的12/ 18 例(66.67 %) 。结论BAI 作为NSCLC ,尤
其是鳞癌的术前辅助治疗,具有一定的近期疗效,与其它辅助治疗具有同样重要的临床意义,是一种特殊的NSCLC
新辅助化疗形式。BAI 后CT 扫描尚不能完全反应残存肿瘤及肿瘤坏死、纤维化等组织学方面的改变,具有局限性。
CYFRA21-1 及动态增强MRI 是具有临床应用价值的疗效监测方法。 |
| 英文摘要: |
| Objective To evaluate the short-term results of preoperative bronchial arterial infusion (BAI) in central nonsmall cell lung cancer (NSCLC) . Methods 20 patients who were confirmed unresectable central NSCLC by imaging underwent preoperative BAI. Results With preoperative BAI ,decreasing in T and N stage was achieved in 5 and 1 case respectively ,decreasing in clinical stage was achieved in 2 cases. 6 cases with squamous carcinoma , 2 cases with adenocarcinoma showed a partial response (PR ,40 %) . Mediastinal lymph nodes were reduced in diameter in 12 cases (66167 %) . Conclusion BAI was proved highly effective with local control before resection for central NSCLC ,especially in patients with
squamous carcinoma. Preoperative BAI was recommended as a specific neoadjuvant chemotherapy for central NSCLC. CT
scan was limited in predicting the pathological changes post-BAI. CYFRA 2.21 and dynamic MRI were useful methods to evaluate clinical status and prognosis post-BAI of patients with NSCLC. |
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