| 李槐,曾辉英,杨玲,刘德忠,姜文浩,李忱瑞,史仲华,周纯武.影响中晚期原发性肝癌远期疗效的因素———以肝动脉化疗栓塞术为主的多模式治疗[J].中国医学影像技术,2000,16(11):930~932 |
| 影响中晚期原发性肝癌远期疗效的因素———以肝动脉化疗栓塞术为主的多模式治疗 |
| A Prognostic Index of the Survival of Patients with Primary Liver Cancer af terMultimodality Treatment Including Transcatheter Arterial Chemoembolization |
| 投稿时间：2000-07-26 |
| DOI： |
| 中文关键词: 原发性肝癌 介入治疗 多模式治疗 Cox 回归模型 生存率 |
| 英文关键词:Primary liver cancer Interventional therapy Multimodality treatment Cox’s hazard proportional model Survival rate |
| 基金项目:本课题为国家“九五”攻关资助项目( 962907203201) 。 |
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| 中文摘要: |
| 目的评价影响中晚期原发性肝癌(以肝动脉化疗栓塞术( TACE) 为主的多模式治疗) 远期疗效的因素。
方法对曾采用TACE 在内的多模式治疗的89 例中晚期原发性肝癌,选择15 个变量,行Cox 回归模型分析影响远
期疗效的因素。结果单因素Cox 回归模型分析结果显示肿瘤在肝内侵犯范围、肿瘤直径、组织类型及TACE 次数
有显著意义( P < 0105) 。Kaplan-Meier 法计算累积中位生存期为45 个月,1～5 年生存率分别为:77106 %、63131 %、
51169 %、23119 %、14159 %。单纯TACE 组总的生存率,长于手术+ TACE 组( P < 0105) 。结论多因素分析和单
因素分析均包含了肿瘤在肝内侵犯范围和肿瘤直径两项因素,说明此两项指标是影响原发性肝癌多模式治疗预后
的重要因素。 |
| 英文摘要: |
| Objective To determine the prognostic factors for primary liver cancer (PLC) after transcatheter chemoembolization ( TACE) that was included in multimodality treatment . Methods 89 patients who underwent multimodality
treatment for PLC from 1994 —1999 were included for Cox′s univariate and multivariate analysis. 15 factors contributed to
the long-term survival rate (SR) were analyzed. Results According to univariate analysis of Cox’s model ,variables significantly associated with SR were the extension of tumor in liver ,staging of tumor ,TACE ,the tumor size and involvement of
lymph nodes ( P < 0.05) . However ,extension of tumor in liver ,the tumor size ,the pathological type of tumor and the times
of TACE were independent factors in multivariate analysis for the long-term SR( P < 0.05) . Kaplan- Meier method proved
the median survival period was 45 months. Cumulative SRs at 1 ,2 ,3 ,4 ,5 years were 77.06 % ,63.31 % ,51.69 % ,23.19 %
and 14.59 % ,respectively. Overall SR was significantly higher in the group of TACE than in the group of TACE after surgical resection ( P < 0.05) . Conclusion The extension of tumor in liver and the tumor size were the determing prognostic
factors. |
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