| 曾辉英,李槐,姜文浩,李洪林,刘德忠,李忱瑞,史仲华,周纯武.肝癌经肝动脉化疗栓塞后Ⅱ期切除的疗效[J].中国医学影像技术,2000,16(11):921~924 |
| 肝癌经肝动脉化疗栓塞后Ⅱ期切除的疗效 |
| Efficacy of Second Stage Resection for Primary Hepatocellular Carcinoma af ter Transcatheter Arterial Chemoembol ization |
| 投稿时间：2000-07-30 |
| DOI： |
| 中文关键词: 肝癌 肝动脉 化疗栓塞 Ⅱ期切除 |
| 英文关键词:Primary hepatocellular carcinoma Hepatic artery Transcatheter arterial chemoembolization Second stage resection |
| 基金项目:本课题受国家“九五”攻关课题基金资助(962907203201) 。 |
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| 中文摘要: |
| 目的探讨不能切除原发性肝癌经肝动脉化疗栓塞( TACE) 后Ⅱ期手术切除的临床疗效。方法36 例
不能切除的原发性肝癌经1～6 次TACE 治疗后获Ⅱ期手术切除,其中22 例手术切除后再行TACE 治疗。化疗药
物选用表阿霉素( EADM) 、丝裂霉素(MMC) 、甲酰四氢叶酸钙(CF) 、52氟尿嘧啶(52FU) 。结果TACE 治疗后有效
率(CR + PR) 为5516 % ,中位生存期为34 个月。1 、2 、3 、4 、5 年累积生存率分别为94.0 %、82.3 %、70.9 %、53.2 %、
53.2 %。结论不能切除的原发性肝癌行TACE ,肿瘤缩小后Ⅱ期切除是延长患者生存期的有效方法, Ⅱ期切除后
肝内复发转移再行TACE 治疗仍能获得较好疗效,延长生存期。 |
| 英文摘要: |
| Objective To evaluate the efficacy of second stage resection after TACE for unresection primary hepatocellular carcinoma. Methods 36 patients with unresection primary hepatocellular carcinoma were treated by TACE for 1～6
times, secondly resected after TACE. Anticancer agents were the combination of epirubicin ( EADM) , mitomycin-C
(MMC) ,calcium folinate (CF) ,fluorouracil (52FU) . Embolization was accomplished with lipiodol ultra-fluide. Of the 36
patients ,22 were treated by TACE after second stage resection. Results The results showed the 1 ,2 ,3 ,4 and 5 years survival rate was 94.0 % ,82.3 % ,70.9 % ,53.2 % and 53.2 %. The median survival period was 36 months. It gained advantage over palliative resection or TACE only. Conclusion These results suggested that second stage resection post-TACE
was beneficial to patients with unresection primary hepatocellular carcinoma. It can be improved the survival of patients.
This prolonged survival could still be obtained by TACE even when recurrence and metastases following second stage resection. |
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