| 宾建平,Robert A Pelberg,刘伊丽,吴风林,陆洁,Sanjiv Kaul.多巴酚丁胺负荷心肌声学造影评价冠状动脉狭窄[J].中国医学影像技术,2000,16(8):643~645 |
| 多巴酚丁胺负荷心肌声学造影评价冠状动脉狭窄 |
| Detection of Coronary Stenosis with Myocardial Contrast Echocardiography during Dobutamine Stress |
| 投稿时间：1999-11-25 |
| DOI： |
| 中文关键词: 心肌声学造影 冠脉狭窄 多巴酚丁胺 心肌血流量 |
| 英文关键词:Coronary stenosis Dobutamine Myocardial blood flow Myocardial contrast echocardiography |
| 基金项目:本研究获国家自然基金资助(编号:39900058) 。 |
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| 中文摘要: |
| 目的 为评价多巴酚丁胺负荷心肌声学造影(MCE) 诊断静息无血流限制冠脉狭窄的准确性。方法 在慢性冠脉狭窄闭胸犬模型上同步进行MCE 和放射性微球测定心肌血流量(MBF) 。结果 负荷状态时,异常冠脉供血区(MBF 储备< 3) 呈现灌注缺损,峰值声强度(VI) 较正常冠脉供血区低(33 ±13 与48 ±14 ; P < 0.01) ;且异常和正常冠脉供血区峰值VI 比值(0.7 ±0.2) 与相应MBF 比值呈良好的线性正相关( r = 0.86 , P < 0.0001) 。结论 多巴酚丁胺可作为一种负荷药物用于MCE 评价冠脉狭窄。 |
| 英文摘要: |
| Objective The aim of this study was to assess the accuracy of myocardial contrast echocardiography (MCE)with dobutamine for detecting non-flow-limitting coronary stenosis. Methods MCE was performed using intravenously injected microbubbles (MRX-115) and radiolabled microspheres were used to measure myocardial blood flow (MBF) in 16closed chest dogs with chronically instrumental coronary stenoses. Results Perfusion defects were seen in abnormal beds(MBF reserve < 3) with dobutamine. The peak video intensity (VI) in the abnormal beds was lower (33 ±13 vs 48 ±14 ;P < 0.01) than in normal beds during dobutamine. An excellent linear relation was noted between the peak VI ratio (0. 7±0. 2 ,abnormal/ normal) and that of MBF using dobutamine ( r = 0. 86 , P < 0.0001) . Conclusion Dobutamine may beused as a stress agent for MCE in detecting coronary stenoses. |
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