| 杨波,关方霞,刘书君,唐艳花,陈喜中,李芳,张正勇,苗沛谦,孟静.复方丹参注射液对兔脑外伤后经颅多普勒和脑水肿的影响[J].中国医学影像技术,2000,16(6):0502~503 |
| 复方丹参注射液对兔脑外伤后经颅多普勒和脑水肿的影响 |
| Effects of Salvia Miltiorrhiza Compostita on Transcranial Doppler and Cerebral Edema after Brain Injury in Rabbits |
| 投稿时间：2000-03-24 |
| DOI： |
| 中文关键词: 脑损伤 经颅多普勒超声 脑水肿 复方丹参 兔 |
| 英文关键词:Brain injury Transcranial Doppler ultrasound Cerebral edema Salvia miltiorrhiza compostita Rabbit |
| 基金项目: |
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| 中文摘要: |
| 目的观察兔脑外伤后应用复方丹参(SMC) 对脑血流速度(BFV) 和脑水肿变化的影响,为临床上脑外伤
后早期应用复方丹参提供参考。方法20 只兔均分为A(对照组) 和B (治疗组) 二组。治疗组(B) 采用复方丹参静
脉注射,A 组同样方法应用等量无菌生理用水。以大脑中动脉血流速度(Vmca) 和脑组织含水量作为观察指标。结
果致伤后第1 天,A、B 二组Vmca 明显下降,第2 、3 、4 天A 组Vmca 分别为(19.1 ±4.3) cm/ s , (17. 9 ±4. 9) cm/ s ,
(19. 7 ±4. 5) cm/ s。B 组分别为(25.6 ±4.6) cm/ s , (24. 5 ±4. 5) cm/ s , (25. 8 ±4. 5) cm/ s。A、B 二组兔脑组织含水量
百分比分别为81.76 ±0.53 和79.05 ±0.54 ,B 组治疗后Vmca 高于A 组,脑含水量低于A 组( P < 0.05) 。结论复
方丹参可改善兔早期脑外伤后的低血流速度,降低脑水肿程度。 |
| 英文摘要: |
| Objective To observe the effects of Salvia miltiorrhiza compostita ( SMC) on brain blood flow velocity
(BFV) and cerebral edema after brain injury ,which could provide auxiliary treatment at early stage of brain injury. Meth-
ods 20 rabbits were classified to 2 groups ,group A(the control group) and B(the treated group) . Group B was given salvia
miltiorrhiza compostita by venous injection while group A was treated with same amount of normal saline in the same way.
The BFV of the middle cerebral artery (Vmca) and moisture in brain tissues were determined to be as index. Results The
Vmca of group A and B obviously decreased at the first day after injury. The Vmca of group A was 19. 1 ±4. 3cm/ s ,17. 9
±4. 9cm/ s and 19. 7 ±4. 5cm/ s respectively at the secondary ,the third and the fourth day. The Vmca of group B was 25.
6 ±4. 6cm/ s ,24. 5 ±4. 5cm/ s and 25. 8 ±4. 5cm/ s separately at the same time as above. Percent of water content in dam-
aged hemisphere in group A and B were 81. 76 ±0. 53 and 79. 05 ±0. 54 respectively. There was significant differences be-
tween the 2 groups in the level of Vmca and brain moisture ( P < 0.05) . Conclusion Salvia miltiorrhiza compostita could
increase Vmca and decrease cerebral edema in rabbits. |
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