| 吉毅峥,刘英棣,周明德,季金娣,陈建,刘超美,陈松旺.自制复方溶石剂1 号的体外溶石及生物学毒性的实验研究[J].中国医学影像技术,2000,16(6):0500~502 |
| 自制复方溶石剂1 号的体外溶石及生物学毒性的实验研究 |
| Experimental Study on Litholytic Compounds No 1-Toxicity Test on Rabbits and Litholysis Efficacy in Vitro |
| 投稿时间：2000-01-21 |
| DOI： |
| 中文关键词: 介入超声 胆结石 溶石剂 |
| 英文关键词:Interventional ultrasonography Gallstone Solvent of gallstone |
| 基金项目: |
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| 中文摘要: |
| 目的评价复方溶石剂1 号的溶石效果和毒性作用。方法体外溶石效果实验和20 只兔胆囊注射溶石
剂后各时间段的血液生化指标变化及各脏器的病理改变。结果复方溶石剂1 号对500mg 的胆固醇结石溶解时间
少于25min (21 ±4.9min) ,对动物的血液生化指标影响不大,除胆囊外未对全身其他脏器造成损害。结论复方溶
石剂1 号是一种新型、安全、高效、低毒的胆固醇结石直接溶石剂。 |
| 英文摘要: |
| Objective To evaluate the efficacy of gallstone dissolution in vitro and the toxicity of the No. 1 litholytic com-
pounds. Methods Experiments was performed to sutdy the efficacy of gallstone dissolution in vitro ,after intra-gallbladder
injection of No. 1 litholytic compounds ,the toxicity was studied both pathological and blood biochemical changes. Results
the No. 1 litholytic compounds dissolved the cholesterol gallstone (500mg) in no more than 25 min (21. 6 ±4. 9 min) ,less
influence to blood biochemical ,no harm to the other organs of rabbits except gallbadder. Conclusion The No. 1 litholytic
compounds is a new and safe cholesterol gallstone contact solvent with efficient and lower toxicity for treatment of cholecys-
tolsithiasis. |
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