| 李爱莉,李治安,刘俐,王新房,杨娅,谢明星,吕清.应用冠脉血流显像技术评价高脂血症患者的冠脉血流储备[J].中国医学影像技术,2000,16(1):0020~23 |
| 应用冠脉血流显像技术评价高脂血症患者的冠脉血流储备 |
| Noninvasive Estimate of Coronary Flow Reserve in Hypercholesterolemic Patients Using Coronary Flow Imaging |
| 投稿时间：1999-10-07 |
| DOI： |
| 中文关键词: 冠脉血流储备 高脂血症 冠脉血流显像 |
| 英文关键词:CRF Hypercholesterolemia Coronary flow imaging |
| 基金项目: |
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| 摘要点击次数: 1924 |
| 全文下载次数: 43 |
| 中文摘要: |
| 目的 应用冠脉血流显像技术结合潘生丁药物负荷试验对单纯高脂血症患者的冠脉血流储备(CFR) 进
行评价,探讨血脂对CFR 的影响。方法 研究对象分为单纯高脂血症组(A 组,30 例) 和正常对照组(B 组,15 例) ,
应用冠脉血流显像技术检测每位受试者静息时的冠脉血流频谱及静脉推注潘生丁(0.56mg/ kg) 后的冠脉血流频谱,
分别用最大充血状态下与静息时的冠脉峰值血流速度(CPV) 比值及速度时间积分(VTI) ×心率(HR) 比值来计算
CFR。结果 静息时,两组的CPV 及VTI ×HR 无明显差别( P > 0.05) 。潘生丁负荷后两组的冠脉血流速度均明显加快,但A 组的CPV 及VTI ×HR 增加程度低于B 组。两组的CFR 值有显著性差别,A 组明显低于B 组( P <0.01) 。相关性分析显示CFR 与TC、LDL-C 呈显著负相关( P < 0.05) 。结论 应用冠脉血流显像新技术结合潘生丁药物负荷试验无创性检测CFR ,可以早期发现高脂血症患者的冠脉储备功能异常,为指导治疗与评估各种降脂措施的疗效提供重要依据。 |
| 英文摘要: |
| Objective This study was performed to investigate the coronary flow reserve (CFR) in hypercholesterolemic
patients using coronary flow imaging combined with dipyridamole stress test . Methods In 30 asymptomatic middle-aged
hypercholesterolemic patients and 15 normal subjects ,the coronary peak velocity (CPV) and coronary velocity-time integral
were measured at basal state and during dipyridamole-induced hyperemia using coronary flow imaging. CFR was difined as
the ratio of CPV or VTI ×HR during maximum pharmacological vasodilation to CPV or VTI ×HR at rest . Results The
baseline CPV and VTI ×HR were similar in the patients and the control subjects ( P > 0. 05) . A significant increase in CPV
and VTI ×HR were observed in both groups after dipyridamole infusion ,but the increasing degree was lower in the patients. Consequently ,CFR was lower in the patients than in the control subjects. Correlative analysis reveal significant nega2
tive correlation of CFR to total cholesterol ( r =-0. 53 , P < 0. 01) and low2density lipoprotein ( r =-0. 55 , P < 0. 001) .
Conclusion Noninvasive coronary flow imaging combined with intravenous dipyridamole may allow early detection of preclinical abnormal CFR in asymptomatic hypercholesterolemic patients and may provide information for treatment and assessment of the cholesterol2lowering therapy effects. |
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