| 刘爽,孙夕林,王凯,吴丽娜.智能响应性磁共振纳米分子成像探针研究进展[J].中国医学影像技术,2020,36(6): |
| 智能响应性磁共振纳米分子成像探针研究进展 |
| Advances in Smart Responsive Magnetic Resonance Nanomolecular Imaging Probe |
| 投稿时间：2020-03-26 修订日期：2020-06-19 |
| DOI： |
| 中文关键词: 智能响应 磁共振成像 纳米分子成像探针 |
| 英文关键词:Smart Response Magnetic Resonance Imaging Nanomolecular Imaging Probe |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）,国家重点基础研究发展计划（973计划），黑龙江省自然科学基金委留学归国科学基金（LC2016034）；哈尔滨医科大学附属第四医院杰出青年基金（HYDSYJQ201601）；黑龙江省高校分子影像重点实验室基金 |
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| 中文摘要: |
| 智能响应性纳米分子探针可以实现肿瘤靶向定位、快速响应、灵敏诊断、精确治疗疾病,这需要精确的成像来监测探针的分布和肿瘤的位置。近年来,磁共振成像(MRI)由于其具有高灵敏度,低背景噪声等特点受到了广泛的关注。磁共振成像作为临床上最为广泛和安全诊断方法之一,为疾病诊断和肿瘤靶向治疗提供影像学指导。研究者对智能响应性MR纳米分子成像探针检测如pH变化、酶活性、还原环境和乏氧等方面进行了深入的研究。这篇文章将对智能响应性磁共振纳米分子成像探针的成像最新研究进展进行综述。 |
| 英文摘要: |
| With the guidance of imaging on the localization of detection probes and tumor, smart responsive nanomolecular probes can realize tumor targeting with the rapid response at the site of the tumor, sensitive diagnosis and precise treatment of diseases. In the past few years, magnetic resonance imaging (MRI) has attracted wide attention due to high sensitivity and low background noise. Magnetic resonance imaging is one of the most extensive and safe diagnostic methods in clinical practice, providing imaging guidance for disease diagnosis and tumor targeted therapy. Smart responsive MR nanomolecular imaging probes were applied in detection of pH changes, enzyme activity, reducing microenvironment, and hypoxia et al. This paper reviewed imaging applications of smart responsive MR nanomolecular imaging probes, which provided an overview on the newest developments of the smart responsive probes for MRI. |
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