| 李艳,邵永佳,席芊,王培军.MRI研究轻度认知障碍大脑连接改变及其机制进展[J].中国医学影像技术,2023,39(10):1583~1586 |
| MRI研究轻度认知障碍大脑连接改变及其机制进展 |
| Progresses of MRI researches on brain connectivity changes and mechanisms of mild cognitive impairment |
| 投稿时间：2023-05-19 修订日期：2023-06-29 |
| DOI：10.13929/j.issn.1003-3289.2023.10.031 |
| 中文关键词: 认知障碍 阿尔茨海默病 磁共振成像 |
| 英文关键词:cognition disorders Alzheimer disease magnetic resonance imaging |
| 基金项目:上海市科学技术委员会科技计划项目(20Y11911700)、上海市浦东新区卫生系统领先人才培养计划(PWRl2022-05)。 |
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| 中文摘要: |
| 阿尔茨海默病(AD)是进行性发展的神经退行性疾病;轻度认知障碍(MCI)是正常衰老与痴呆之间的过渡状态,为预防性治疗AD的关键阶段。弥散张量成像(DTI)和血氧水平依赖功能MRI(BOLD-fMRI)常用于评估大脑结构及功能连接及解释其相关机制。本文就MRI研究MCI大脑连接改变及其机制进展进行综述。 |
| 英文摘要: |
| Alzheimer's disease (AD) is a progressive neurodegenerative disease. Mild cognitive impairment (MCI) is a transitional state between normal aging and dementia, also the critical stage for preventive treatment of AD. Diffusion tensor imaging (DTI) and blood oxygenation level dependent functional MRI (BOLD-fMRI) were commonly used to evaluate structural and functional connectivity of brain and explain related mechanisms. The progresses of MRI researches on brain connectivity changes and mechanisms of MCI were reviewed in this article. |
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