严子淳,陈晓娅,曾春,郑桥,史卓伟,李咏梅.多序列MRI评估复发缓解型多发性硬化患者大脑皮层厚度改变[J].中国医学影像技术,2022,38(7):984~988
多序列MRI评估复发缓解型多发性硬化患者大脑皮层厚度改变
Multi-sequence MRI evaluation on changes of cerebral cortical thickness in patients with relapsing-remitting multiple sclerosis
投稿时间:2021-11-10  修订日期:2022-03-18
DOI:10.13929/j.issn.1003-3289.2022.07.005
中文关键词:  多发性硬化,复发缓解型  大脑皮层  磁共振成像
英文关键词:multiple sclerosis,relapsing-remitting  cerebral cortex  magnetic resonance imaging
基金项目:重庆市技术创新与应用发展专项大健康领域重点研发项目(CSTC2021jscx-gksb-N0008)。
作者单位E-mail
严子淳 重庆医科大学附属第一医院放射科, 重庆 400016  
陈晓娅 重庆医科大学附属第一医院放射科, 重庆 400016  
曾春 重庆医科大学附属第一医院放射科, 重庆 400016  
郑桥 重庆医科大学附属第一医院放射科, 重庆 400016  
史卓伟 重庆医科大学附属第一医院放射科, 重庆 400016  
李咏梅 重庆医科大学附属第一医院放射科, 重庆 400016 lymzhang@aliyun.com 
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中文摘要:
       目的 观察多序列MRI所示复发缓解型多发性硬化(RRMS)患者大脑皮层厚度改变,并探讨其与皮层病灶及认知功能损害之间的相关性。方法 纳入41例RRMS患者(RRMS组)及30名健康人(对照组),比较其数字广度测验(DST)及符号数字转换测验(SDMT)评分。基于颅脑3D-T1W、液体衰减反转恢复(FLAIR)及双反转恢复(DIR)序列获取2组颅脑体积、皮层厚度及RRMS组皮层病灶数量和体积,分析RRMS组皮层厚度与皮层病灶数量、病灶体积及临床认知量表评分的相关性。结果 RRMS组DST及SDMT评分均低于对照组(P均<0.05),灰质体积小于对照组(P<0.05),白质体积大于对照组(P<0.05)。于36例(36/41,87.80%)RRMS共检出186个皮层病灶,总体积为16 880 mm3。相比对照组,RRMS组皮层萎缩范围更广(P均<0.05),主要集中于额叶和颞叶,且部分脑区皮层萎缩与皮层病灶数量、体积及DST评分具有相关性(P均<0.05)。结论 RRMS患者存在广泛大脑皮层萎缩,并与皮层病灶数量、体积及认知功能损害存在相关性。
英文摘要:
      Objective To observe the changes of cerebral cortical thickness in patients with relapsing-remitting multiple sclerosis (RRMS) with multi-sequence MRI, and to investigate the correlations with cortical lesions and cognitive impairment. Methods A total of 41 RRMS patients (RRMS group) and 30 healthy subjects (control group) were enrolled, and the digit span test (DST) and symbol digit modalities test (SDMT) scores were compared between groups. Based on brain 3D-T1WI, fluid attenuated inversion recovery (FLAIR) and double inversion recovery (DIR) sequences, the brain volume, cortical thickness of 2 groups, as well as he number and volume of cortical lesions in RRMS group were obtained. The correlations of cortical thickness with the number, volume of cortical lesions and clinical cognitive scale scores of RRMS patients were analyzed. Results In RRMS group, DST and SDMT scores were lower, the volume of gray matter was smaller, while the volume of white matter was greater than those in control group (all P<0.05). Totally 186 lesions cortical lesions were detected in 36 (36/41, 87.80%) RRMS patients, with a total volume of 16 880 mm3. Compared with control group, cortical atrophies were more extensive in RRMS group (all P<0.05), mainly in the frontal lobe and temporal lobe, and cortical atrophy in some brain regions were correlated with the number, volume of cortical lesions and DST scores (all P<0.05). Conclusion RRMS patients had extensive cerebral cortical atrophy, being correlated with the number, volume of cortical lesions and cognitive impairment.
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