高超,孙莹莹,孙夕林.影像组学在18F-FDG PET/CT研究进展及临床应用[J].中国医学影像技术,2020,36(8):1239~1242 |
影像组学在18F-FDG PET/CT研究进展及临床应用 |
Research progresses and clinical application of radiomics in 18F-FDG PET/CT |
投稿时间:2020-02-20 修订日期:2020-07-09 |
DOI:10.13929/j.issn.1003-3289.2020.08.028 |
中文关键词: 氟脱氧葡萄糖F18 正电子发射断层显像 体层摄影术,X线计算机 影像组学 |
英文关键词:fluorodeoxyglucose F18 positron-emission tomography tomography,X-ray computed radiomics |
基金项目:国家自然科学基金(81627901)、国家重点基础研究发展计划(2015CB931800)。 |
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中文摘要: |
近年来,PET临床应用发展迅速,借助18F-FDG或多种类型在体放射性分子示踪剂,可无创地从功能及分子水平提供活体内肿瘤信息。影像组学是基于计算机学习的医学影像分析方法。微观分子水平上的基因或蛋白质变化可在宏观影像图片上有所体现。深度挖掘影像特征,可反映人体组织、细胞和基因水平变化,预测和评估肿瘤异质性。本文聚焦于影像组学流程和研究重点、难点及18F-FDG PET影像组学临床应用,对目前18F-FDG PET影像组学预测肿瘤分子分型相关进展进行综述。 |
英文摘要: |
In recent years, clinical applications of PET developed rapidly. With 18F-FDG and other types in vivo radioactive molecular tracers, PET can provide tumor information in vivo from the functional and molecular levels. Radiomics is a medical imaging analysis approach based on computer learning. In the microscopic molecular level, changes of gene or protein can be reflected in macroscopic image pictures. Through deep mining of image features, the changes of human tissue, cells and genes can be reflected for predicting and evaluating the heterogeneity of tumors. The process of imaging omics and the key and difficult points of research and clinical applications of 18F-FDG PET imaging omics were focused, and the current progresses of 18F-FDG PET in imaging histology for predicting tumor molecular subtypes were reviewed in this article. |
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