张宁,李继元,岳云龙,邵永聪,金延方,刘洪亮.静息态fMRI观察经颅电刺激对睡眠剥夺后青年志愿者后扣带回皮质连接紊乱的干预作用[J].中国医学影像技术,2020,36(8):1163~1167
静息态fMRI观察经颅电刺激对睡眠剥夺后青年志愿者后扣带回皮质连接紊乱的干预作用
Resting state fMRI observation on effect of transcranial direct current stimulation on cortical connectivity dysfunction of posterior cingulate cortex in young volunteers after sleep deprivation
投稿时间:2019-12-04  修订日期:2020-05-07
DOI:10.13929/j.issn.1003-3289.2020.08.010
中文关键词:  睡眠剥夺  扣带回  经颅直流电刺激  磁共振成像
英文关键词:sleep deprivation  gyrus cingula  transcranial direct current stimulation  magnetic resonance imaging
基金项目:首都医科大学附属北京世纪坛医院科研课题(2017-q42)。
作者单位E-mail
张宁 首都医科大学附属北京世纪坛医院磁共振室, 北京 100038  
李继元 首都医科大学附属北京世纪坛医院磁共振室, 北京 100038  
岳云龙 首都医科大学附属北京世纪坛医院磁共振室, 北京 100038 yunlongwxh@sina.com 
邵永聪 军事医学科学院基础医学研究所, 北京 100010  
金延方 首都医科大学附属北京世纪坛医院磁共振室, 北京 100038  
刘洪亮 首都医科大学附属北京世纪坛医院磁共振室, 北京 100038  
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中文摘要:
      目的 采用静息态功能MRI(rs-fMRI)观察经颅电刺激(tDCS)对睡眠剥夺(SD)后青年志愿者双侧后扣带回皮质(PCC)功能连接紊乱的干预作用。方法 对16名健康志愿者间隔施加2次24 h SD,随后随机给予真/假tDCS,于正常睡眠清醒休息状态(RW)、SD后及真/假tDCS后采集fMRI数据并进行蒙特利尔认知评估(MoCA),选取双侧PCC作为种子点,计算种子点与全脑间功能连接,观察RW、SD后及真/假tDCS组间功能连接变化,比较MoCA差异。结果 SD后受试者平均MoCA分值较RW减低(t=8.047,P<0.05);真tDCS后平均MoCA分值(27.06±1.53)高于假tDCS后(25.13±1.86,t=-3.081,P=0.008)和SD后(24.75±2.41,t=3.306,P=0.005)。SD后双侧PCC与双侧丘脑功能连接较RW上升,而与右侧楔前叶功能连接下降。真tDCS后双侧PCC与双侧丘脑间功能连接较假tDCS后下降,而左侧PCC与右侧楔前叶间功能连接上升。结论 24 h SD能引起PCC网络连接紊乱;tDCS对SD所致网络功能连接紊乱具有一定干预作用。
英文摘要:
      Objective To observe the effect of transcranial direct current stimulation (tDCS) on dysfunction of bilateral posterior cingulate cortex (PCC) in young volunteers after sleep deprivation (SD) with resting state functional MRI (rs-fMRI). Methods Totally 16 healthy subjects who underwent 24 h SD twice at intervals were randomly given tDCS/sham tDCS SD. fMRI data and Montreal cognitive assessment (MoCA) scores were collected after rest wakefulness (RW), SD and tDCS, respectively. Bilateral PCC were selected as the seed points to calculate the functional connection between the seed points and the whole brain. The changes of functional connection between the above three time points and tDCS/sham tDCS were observed, and the differences of MoCA scores were compared. Results The mean score of MoCA in SD subjects was lower than that in RW (t=8.047, P<0.05), while the mean score of MoCA after tDCS was higher (27.06±1.53) than that after sham tDCS (25.13±1.86, t=-3.081, P=0.008) and 24 h SD (24.75±2.41, t=3.306, P=0.005). Compared with RW, functional connection between PCC and thalamus increased, while between PCC and right anterior cuneiform lobe decreased. Compared with that after tDCS, functional connection in bilateral thalamus decreased after tDCS, whereas in the left PCC and the right anterior cuneiform lobe increased. Conclusion 24 h SD can cause extensive connectivity dysfunction of PCC network. tDCS has certain regulatory effect on the network functional connectivity disorders caused by SD.
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