| 许翔,刘新秀,陈玲,曾锦树,叶新鲜,黄小花,魏凌琳,包中涛.妊娠期糖尿病对孕妇血管内皮功能的影响[J].中国医学影像技术,2020,36(6):893~897 |
| 妊娠期糖尿病对孕妇血管内皮功能的影响 |
| Impact of gestational diabetes mellitus on vascular endothelial function in pregnant women |
| 投稿时间：2019-09-13 修订日期：2020-05-06 |
| DOI：10.13929/j.issn.1003-3289.2020.06.021 |
| 中文关键词: 糖尿病,妊娠 超声检查,多普勒,彩色 内皮,血管 血管舒张 |
| 英文关键词:diabetes, gestational ultrasonography, Doppler, color endothelium, vascular vasodilation |
| 基金项目:福建省卫生计生科研人才培养项目（2017-ZQN-49）。 |
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| 中文摘要: |
| 目的 探讨GDM对孕妇血管内皮功能的影响及内皮依赖性血流介导血管扩张（FMD）技术的临床价值。方法 采用内皮依赖性FMD技术于孕前、孕中期和产后12周评估29例GDM孕妇（观察组）和34名正常妊娠孕妇（对照组）的右侧肱动脉FMD值；记录2组临床资料，包括年龄、心率、体质量指数、收缩压、舒张压、总胆固醇、三酰甘油及口服葡萄糖耐量试验（OGTT）结果。比较组间临床资料，分析组间及组内不同时间点FMD值差异，分析影响观察组FMD值的因素。结果 FMD值在2组均呈先降后升趋势，观察组（F=85.50）及对照组（F=89.59）之间及组内3个时间点间差异均有统计学意义（P均<0.05）；3个时间点组间差异亦有统计学意义（F=39.01，P<0.05）。孕前组间FMD值差异无统计学意义（F=0.68，P>0.05），对照组孕中期（F=16.88）和产后12周（F=60.83）FMD值均大于观察组（P均<0.05）。服糖后2 h血糖和舒张压对FMD值影响最为显著。结论 GDM可致孕妇血管内皮功能不可逆损伤。利用FMD技术可无创评价GDM患者血管内皮功能，有望为筛查GDM孕妇产后心脑血管病提供新的手段。 |
| 英文摘要: |
| Objective To explore the impact of gestational diabetes mellitus (GDM) on vascular endothelial function in pregnant women with endothelium-dependent flow-mediated dilatation (FMD) technology, and to observe the clinical value of FMD. Methods Totally 29 pregnant women with GDM (observation group) and 34 normal pregnant women (control group) were collected. Endothelium-dependent FMD technology was used to obtain the right brachial artery FMD value before pregnancy, on the metaphase of pregnancy and 12 weeks postpartum. Clinical data, including pregnant women's age, heart rate, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride and oral glucose tolerance test (OGTT) results were recorded and compared between 2 groups. FMD values were analyzed between groups and within group at different time points, and the impact factors of FMD values were explored. Results FMD values showed first downward and then rising trend in both 2groups. Statistical differences of FMD values were found between observation group (F=85.50) and control group (F=89.59) at all 3 time points (all P<0.05), also at 3 time points between groups (F=39.01, P<0.05).There was no statistical difference of FMD values between 2 groups before pregnancy (F=0.68, P>0.05), while FMD of metaphase pregnancy (F=16.88) and 12 weeks postpartum (F=60.83) in control group were both larger than in observation group (both P<0.05).Blood glucose 2 hours after taking sugar and diastolic blood pressure had obvious impact on FMD value. Conclusion GDM may lead to irreversible vascular endothelial dysfunction in pregnant women. Using FMD technology can noninvasively evaluate vascular endothelial function of GDM, which is expected to provide a new way for screening postpartum cardiovascular and cerebrovascular diseases in GDM pregnant women. |
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