| 冼伟均,冯彦林,杨明,王颖,鲁胜男.双时相18F-FDG PET/CT显像诊断不同类型肝外胆管癌[J].中国医学影像技术,2020,36(6):878~882 |
| 双时相18F-FDG PET/CT显像诊断不同类型肝外胆管癌 |
| Dual-phase 18F-FDG PET/CT in diagnosis of different types of extrahepatic cholangiocarcinomas |
| 投稿时间：2019-05-11 修订日期：2020-01-15 |
| DOI：10.13929/j.issn.1003-3289.2020.06.017 |
| 中文关键词: 胆管肿瘤 正电子发射断层显像术 体层摄影术,X线计算机 氟脱氧葡萄糖F18 |
| 英文关键词:bile duct neoplasms positron-emission tomography tomography, X-ray computed fluorodeoxyglucose F 18 |
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| 中文摘要: |
| 目的 探讨双时相18F-FDG PET/CT显像诊断不同类型肝外胆管癌（EHCC）的价值。方法 回顾性分析71例疑诊EHCC并接受双时相18F-FDG PET/CT显像患者，根据PET/CT显像及病理结果将其分为结节型EHCC组（n=20）、非结节型EHCC组（n=34）及良性病变组（n=17），计算双时相PET/CT显像的诊断效能；比较双时相PET/CT显像中3组阳性显像病灶最大标准摄取值（SUVmax）、肿瘤SUVmean/肝脏SUVmax（T/L）及滞留指数（RI）的差异，以ROC曲线比较各参数AUC，并分析其临界值。结果 早期18F-FDG PET/CT显像及延迟显像对非结节型EHCC的诊断灵敏度分别为70.59%（24/34）和73.53%（25/34）。显像阳性患者中，结节型EHCC组SUVmax、T/L均明显高于良性病变组（P均<0.05）。非结节型EHCC组SUVmax、T/L与良性病变组差异均无统计学意义（P均>0.05），但SUV滞留指数（RISUV）差异存在统计学意义（Z=-2.638，P=0.007），RISUV最佳诊断临界值为6.0%。联合应用早期SUVmax>3.1和RISUV>6.0%可明显提高对非结节型EHCC的诊断灵敏度和准确率。结论 双时相18F-FDG PET/CT显像有助于提高对非结节型EHCC的诊断效能。 |
| 英文摘要: |
| Objective To explore the value of dual-phase 18F-FDG PET/CT in diagnosis of different types of extrahepatic cholangiocarcinomas (EHCC). Methods Data of 71 patients with suspected EHCC who underwent preoperative dual-phase 18F-FDG PET/CT scanning were retrospectively analyzed. According to 18F-FDG PET/CT imaging and pathological results, the patients were divided into mass-forming EHCC group (n=20), non-mass-forming EHCC group (n=34) and benign diseases group (n=17). The diagnostic efficiency of dual-phase 18F-FDG PET/CT was calculated. The maximal standardized uptake value (SUVmax), tumor SUVmax/liver SUVmean ratio (T/L) and retention index (RI) of dual-phase 18F-FDG PET/CT were compared in those with positive findings among 3 groups. ROC curves were used, and the AUC were compared. Results The diagnostic sensitivity of early and delayed 18F-FDG PET/CT for non-mass-forming EHCC was 70.59% (24/34) and 73.53% (25/34), respectively. In all patients with positive findings, SUVmax and T/L of mass-forming EHCC were higher than those of benign diseases (all P<0.05). There was significant difference of retention index of SUV (RISUV, Z=-2.638, P=0.007) but not of SUVmax nor T/L between non-mass-forming EHCC group and benign diseases group (all P>0.05). The best cut-off of RISUV was 6.0%. The diagnostic sensitivity and accuracy of dual-phase 18F-FDG PET/CT for non-mass-forming EHCC can be improved with the combination of early phase SUVmax>3.1 and RISUV>6.0%. Conclusion Dual-phase 18F-FDG PET/CT might be helpful to improving diagnostic accuracy of non-mass-forming EHCC. |
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