| 刘安宁,刘晗,李玉宏.极速脉搏波速度技术评价维生素D缺乏对2型糖尿病患者早期颈动脉弹性功能的影响[J].中国医学影像技术,2020,36(6):839~843 |
| 极速脉搏波速度技术评价维生素D缺乏对2型糖尿病患者早期颈动脉弹性功能的影响 |
| Ultrafast pulse wave velocity technique in assessment of impacts of vitamin D deficiency on early carotid elasticity in patients with type 2 diabetes |
| 投稿时间：2019-05-31 修订日期：2020-05-25 |
| DOI：10.13929/j.issn.1003-3289.2020.06.008 |
| 中文关键词: 糖尿病,2型 维生素D缺乏 颈动脉 弹性 极速脉搏波速度 |
| 英文关键词:diabetes mellitus, type 2 vitamin D deficiency carotid arteries elasticity ultrafast pulse wave velocity |
| 基金项目:辽宁省自然科学基金（20170540381）、辽宁省兴辽英才计划（XLYC1802049）。 |
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| 中文摘要: |
| 摘要 ]目的 应用极速脉搏波速度（UFPWV）技术观察维生素D缺乏对2型糖尿病（T2DM）患者早期颈动脉弹性功能的影响。方法 根据25-羟维生素D3[25（OH）D3]水平将92例T2DM患者（T2DM组）分为维生素D缺乏亚组和维生素D非缺乏亚组，以1 544名健康成人为对照组，记录2组临床资料及实验室指标，应用UFPWV技术测量颈动脉弹性参数，包括收缩期起始及结束时脉搏波速度（PWV-BS、PWV-ES），对上述数据进行统计学分析。结果 ① T2DM组中，维生素D缺乏亚组体质量指数（BMI）、空腹血糖（FPG）、收缩压、舒张压、总胆固醇（TC）、甘油三酯、PWV-BS、PWV-ES水平均高于非缺乏亚组（P均<0.05），高密度脂蛋白胆固醇（HDL-C）水平低于维生素D非缺乏组（P<0.05）。②Pearson相关分析发现，PWV-BS、PWV-ES与年龄、BMI、FPG、收缩压、舒张压及TC呈正相关（P均<0.05），与25（OH）D3、HDL-C呈负相关（P均<0.05）。③多元线性逐步回归分析显示，FPG、收缩压、年龄及TC是PWV-BS、PWV-ES的危险因素（P均<0.05），25（OH）D3是PWV-ES的保护因素（P<0.05）。结论 维生素D缺乏T2DM患者PWV-BS、PWV-ES明显升高；维生素D可能是T2DM患者颈动脉硬化的保护因素，监测T2DM患者维生素水平并及时补充维生素D或可延缓其并发症发生发展。 |
| 英文摘要: |
| Objective To explore the impacts of vitamin D deficiency on early carotid elasticity in patients with type 2 diabetes mellitus (T2DM) using ultrafast pulse wave velocity (UFPWV) technique. Methods A total of 92 patients with T2DM were enrolled (T2DM group) and divided into vitamin D deficiency subgroup and vitamin D non-deficiency subgroup according to the level of 25-hydroxyvitamin D3 (25[OH]D3), while 1 544 normal adults were taken as controls(control group). UFPWV technique was used to measure carotid elasticity parameters, including pulse wave velocity at the beginning of systole (PWV-BS) and the end of systole (PWV-ES), and clinical data and laboratory indicators of both groups were collected. Then statistical analysis of the above data was performed. Results ①Among T2DM group, the levels of body mass index (BMI), fasting blood glucose (FPG), systolic blood pressure, diastolic blood pressure, total cholesterol (TC), triglyceride, PWV-BS and PWV-ES of vitamin D deficiency subgroup were higher than those of non-deficient subgroup (all P<0.05), while the level of high density lipoprotein cholesterol (HDL-C) was lower than that of the vitamin D non-deficient subgroup (P<0.05). ②Pearson correlation analysis showed that PWV-BS and PWV-ES were positively correlated with age, BMI, FPG, systolic blood pressure, diastolic blood pressure and TC (all P<0.05) but negatively correlated with 25(OH)D3 and HDL-C (P<0.05). ③Multivariate linear stepwise regression analysis showed that FPG, systolic blood pressure, age and TC were risk factors for PWV-BS and PWV-ES (all P<0.05), whereas 25(OH)D3 was a protective factor for PWV-ES (P<0.05). Conclusion PWV-BS and PWV-ES values in T2DM patients with vitamin D deficiency significantly elevated. Vitamin D may be a protective factor for carotid elasticity in patients with T2DM. Monitoring vitamins level in T2DM patients is promptly supplemented. Vitamin D may delay the development of T2DM complications. |
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