王钧波,季敏,杨皓玮,沈全力,龚英,乔中伟.口服钆双胺稀释液在小儿磁共振胰胆管成像中的应用[J].中国医学影像技术,2020,36(3):429~432
口服钆双胺稀释液在小儿磁共振胰胆管成像中的应用
Application of oral administration of diamine diluent before magnetic resonance cholangiopancreatography in children
投稿时间:2019-03-13  修订日期:2019-12-27
DOI:10.13929/j.issn.1003-3289.2020.03.029
中文关键词:  儿童  胰胆管造影术,磁共振  造影剂
英文关键词:child  cholangiopancreatography,magnetic resonance  contrast media
基金项目:
作者单位E-mail
王钧波 复旦大学附属儿科医院放射科, 上海 201102  
季敏 复旦大学附属儿科医院放射科, 上海 201102  
杨皓玮 复旦大学附属儿科医院放射科, 上海 201102  
沈全力 复旦大学附属儿科医院放射科, 上海 201102  
龚英 复旦大学附属儿科医院放射科, 上海 201102  
乔中伟 复旦大学附属儿科医院放射科, 上海 201102 qiaozhwei@163.com 
摘要点击次数: 1734
全文下载次数: 571
中文摘要:
      目的 观察口服稀释钆双胺注射液(欧乃影)作为小儿胃肠道阴性对比剂对改善磁共振胰胆管成像(MRCP)图像质量、提高胰胆管显示率的可行性。方法 对浓度为0.20%、0.30%、0.50%钆双胺稀释液与纯水同时行MR扫描,计算各浓度对比剂信号衰减率。将282例接受MRCP患儿分为观察组(244例疑似肝胆疾病患儿)和对照组(38例非肝胆疾病患儿)。检查前1 h嘱观察组患儿口服0.50%钆双胺稀释液400 ml,于45 min内摄入,15 min后进行检查。对所有图像进行评分,以评分≥3分不影响诊断为合格标准,计算图像质量合格率。采用Kappa系数检验2名医师评估图像质量结果的一致性,比较2组MRCP图像质量合格率,分析性别对图像质量合格率的影响。结果 浓度为0.20%、0.30%及0.50%钆双胺稀释液的信号衰减率分别为76.67%、88.47%及98.33%;0.50%钆双胺稀释液抑水效果最佳,故以0.50%钆双胺稀释液为小儿胃肠道阴性对比剂。2名医师对所有图像质量评分结果一致性强(Kappa=0.85,P<0.01)。观察组图像合格率(97.13%)显著高于对照组(47.37%,χ2=94.04,P<0.01)。不同性别图像合格率差异无统计学意义(χ2=0.01,P>0.05)。结论 口服浓度0.50%钆双胺稀释液可有效抑制小儿胃肠道液体高信号,改善MRCP图像质量。
英文摘要:
      Objective To observe the feasibility of oral administration of diluted gadolinium diamine injection as negative contrast agent for gastrointestinal tract for improving imaging quality and displaying pancreaticobiliary duct during magnetic resonance cholangiopancreatography (MRCP) in children. Methods MRI of gadolinium diamine diluent with concentrations of 0.20%, 0.30% and 0.50% and pure water were performed at the same time, then the signal attenuation rate of each concentration of contrast agent was calculated. A total of 282 children received MRCP were divided into experimental group (244 children with suspected hepatobiliary diseases) and control group (38 children with non-hepatobiliary diseases). One hour before examination, children in experimental group were asked to orally take 0.50% gadolinium diamine diluent 400 ml within 45 min, and then underwent MRCP 15 min later. All images were scored by 2 imaging physicians, and the imaging qualified rate of was calculated taken ≥ 3 points and not affecting diagnosis as qualified standards. Kappa coefficient was used to test the consistency of image quality assessments of 2 doctors, and the differences of imaging qualified rate were compared between 2 groups and different genders. Results The signal attenuation rate of the concentration of 0.20%, 0.30% and 0.50% gadolinium diamine diluents was 76.67%, 88.47% and 98.33%, respectively. The 0.50% gadolinium diamine diluent had the best water inhibition effect, and was selected as the negative contrast agent for children gastrointestinal tract. The consistency of results of imaging quality scores by 2 doctors was good (Kappa=0.85, P<0.01). MRCP imaging qualified rate of experimental group (97.13%) was significantly higher than that of control group (47.37%, χ2=94.04, P<0.01). No statistical difference of imaging qualified rate was found between males and females (χ2=0.01, P>0.05). Conclusion Oral administration of 0.5% concentration of gadolinium diamine diluent can effectively inhibit high gastrointestinal fluid signals and significantly improve imaging quality of MRCP in children.
查看全文  查看/发表评论  下载PDF阅读器