| 师美娟,梁志冉,沈聪,魏霞,杨全新,金晨望,郭佑民.基于体素观察慢性阻塞性肺疾病肺叶损伤程度及空间分布[J].中国医学影像技术,2020,36(3):340~344 |
| 基于体素观察慢性阻塞性肺疾病肺叶损伤程度及空间分布 |
| Injury degree and spatial distribution of pulmonary lobe of chronic obstructive pulmonary disease using voxel-based morphometry |
| 投稿时间：2019-06-28 修订日期：2020-01-20 |
| DOI：10.13929/j.issn.1003-3289.2020.03.004 |
| 中文关键词: 肺疾病,慢性阻塞性 肺叶 体层摄影术,X线计算机 |
| 英文关键词:pulmonary disease,chronic obstructive lobe tomography,X-ray computed |
| 基金项目:国家卫生和计划生育委员会《基于数字肺的呼吸系统疾病评价体系与诊断标准研究》公益性行业科研专项基金（201402013）。 |
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| 中文摘要: |
| 目的 探讨基于体素定量CT分析慢性阻塞性肺疾病（COPD）患者肺叶损伤程度及空间分布的价值。方法 在"数字肺"多研究中心连续性纳入接受双气相扫描COPD患者，测定小气道病变（fSAD）和肺气肿（Emph）的定量值；分析患者各肺叶之间Emph、fSAD肺叶损伤程度及肺叶分布的差异，以及各肺叶定量CT分布与肺功能的相关性。结果 最终纳入50例COPD患者。Emph和fSAD均以右肺中叶最重，两肺上叶次之，两肺下叶程度最轻；Emph和fSAD均主要分布于左肺上叶，其次为右肺上叶，右肺中叶分布最少。两肺下叶Emph和fSAD与FEV1%的相关性较好。结论 COPD患者肺叶损伤程度以右肺中叶及两肺上叶为重，尤其是右肺中叶；Emph和fSAD主要分布于左肺上叶，其次是右肺上叶；两肺下叶损伤对COPD患者肺功能的影响更著。 |
| 英文摘要: |
| Objective To exlpore the value of voxel-based quantitative CT in evaluation on injury degree and spatial distribution in different lobes of chronic obstructive pulmonary disease (COPD) patients. Methods COPD patients who underwent inspired and expired CT scanning were consecutively recruited from the multi-center study named Digital Lung.Quantitative parametres of functional small-airway disease (fSAD) and emphysema (Emph) were measured. The degree and distribution of pulmonary lobar injury were analyzed according to Emph and fSAD among different pulmonary lobes. At the same time, the correlation of quantitative CT distribution and lung function of each lobe was analyzed. Results A total of 50 COPD patients were eventually included. Emph and fSAD of the right middle lobe (RML) was the most severe, followed by the upper lobes of the two lungs, while the lowest degree of injury were seen in both lower lobes of the lungs. Emph and fSAD were both mainly distributed in the left upper lobe (LUL), followed by in the right upper lobe (RUL), while in the right middle lobe (RML) was the least. Either fSAD or Emph showed better correlations with FEV1% in both lower lobes. Conclusion The injury of the lobes in COPD patients mainly distribute in the RML and both upper lobes, especially the former. Emph and fSAD mainly distribute in the LUL, followed by the RUL. The lower lobes of the lungs have greater influence on pulmonary function in COPD patients. |
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