| 裘雅各,吴小伟,汪耀,孙雅文,丁伟娜,韩旭,周滟.多模态MRI评价皮层下血管性认知功能障碍白质高信号半暗带[J].中国医学影像技术,2020,36(1):32~36 |
| 多模态MRI评价皮层下血管性认知功能障碍白质高信号半暗带 |
| Multimodal MRI in evaluating white matter hyperintensity penumbras in patients with subcortical vascular cognitive impairment |
| 投稿时间：2019-03-03 修订日期：2019-12-27 |
| DOI：10.13929/j.issn.1003-3289.2020.01.009 |
| 中文关键词: 脑功能障碍 半暗带 磁共振成像 |
| 英文关键词:cognitive dysfunction penumbra magnetic resonance imaging |
| 基金项目:上海市科委西医引导项目（17411964300）、上海交通大学高峰高原"双百人"计划（20172013）、国家自然科学基金（81901693）、上海交通大学医工交叉项目（NoYG2017QN47）、上海交通大学医学院附属仁济医院临床科研创新培育基金计划（PYIV-17-003）、仁济医院科研种子基金（RJZZ18-003）。 |
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| 中文摘要: |
| 目的 探讨不同MR成像技术评价皮层下血管性认知功能障碍（SVCI）患者脑白质高信号（WMH）半暗带（WMH-P）的价值。方法 对29例SVCI患者行弥散加权成像（DTI）、三维动脉自旋标记（3D-ASL）和酰胺质子化学交换饱和转移（CEST APT）扫描及神经心理学评估。将WMH周围1 cm范围为定义WMH-P，分别测量WMH、WMH-P及WMH-P以外正常表观白质（NAWM）的各项成像参数值，并与认知评分进行相关性分析。结果 FA和MD值在WMH、WMH-P及WMH-P以外NAWM之间差异均有统计学意义（P均<0.05），脑血流量（CBF）在WMH-P与WMH-P以外NAWM以及WMH与WMH-P以外NAWM之间均有统计学意义（P均<0.05）。WMH-P和WMH-P以外NAWM的FA值与MoCA评分呈显著正相关（P均<0.05）。结论 DTI技术与3D-ASL能反映SVCI患者脑白质病变范围及进展趋势；WMH-P的FA值能较好地评价SVCI患者认知功能水平。 |
| 英文摘要: |
| Objective To explore the value of different MR techniques in evaluating white matter hyperintensity (WMH) penumbra (WMH-P) in patients with subcortical vascular cognitive impairment (SVCI). Methods A total of 29 SVCI patients underwent diffusion weight imaging (DTI), 3D-arterial spin labeling (3D-ASL) and chemical exchange saturation transfer amide proton transfer (CEST APT) scans as well as neuropsychological evaluation. WMH-P was defined in the range of 1 cm around WMH. Imaging parameters of WMH, WMH-P and normal appearing white matter (NAWM) outside WMH-P were measured and analyzed with cognitive scores. Results There were significant differences of FA and mean diffusivity MD values among WMH, WMH-P and NAWM outside WMH-P (all P<0.05), also of cerebral blood flow (CBF) between WMH-P and NAWM outside WMH-P, as well as between WMH and NAWM outside WMH-P (all P<0.05). FA value in WMH-P and NAWM outside WMH-P was positively correlated with Montreal cognitive assessment (MoCA) scores (all P<0.05). Conclusion 3D-ASL and DTI techniques can be used to reflect the extent and progression of white matter lesions in patients with SVCI. FA value of WMH-P can well evaluate the cognitive function of SVCI patients. |
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