王佳,姚飞荣,胡竞成,毛青,付乃奇,李红,胡春洪.基于多回波肝脏内插容积激发成像评价大鼠非酒精性脂肪肝[J].中国医学影像技术,2020,36(1):27~31
基于多回波肝脏内插容积激发成像评价大鼠非酒精性脂肪肝
Evaluation of rat nonalcoholic fatty liver based on multi-echo liver interpolated volume excitation imaging
投稿时间:2019-04-08  修订日期:2019-11-13
DOI:10.13929/j.issn.1003-3289.2020.01.007
中文关键词:  非酒精性脂肪肝  大鼠  磁共振成像
英文关键词:nonalcoholic fatty liver disease  rat  magnetic resonance imaging
基金项目:江苏省数字创新诊疗装备应用示范研究项目(2017YFC0114300)。
作者单位E-mail
王佳 苏州大学附属第一医院放射科, 江苏 苏州 215006  
姚飞荣 苏州大学附属第一医院放射科, 江苏 苏州 215006  
胡竞成 苏州大学附属第一医院内分泌科, 江苏 苏州 215006  
毛青 苏州朗润医疗系统有限公司, 江苏 苏州 215126  
付乃奇 苏州朗润医疗系统有限公司, 江苏 苏州 215126  
李红 苏州大学生物化学与分子生物学系, 江苏 苏州 215123  
胡春洪 苏州大学附属第一医院放射科, 江苏 苏州 215006 hch5305@163.com 
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中文摘要:
      目的 观察多回波肝脏内插容积激发成像(mLIVE)诊断非酒精性脂肪肝大鼠的价值。方法 选取64只雌性SD大鼠,随机分为实验组(n=40)及对照组(n=24),实验组喂饲高脂饮食、对照组给予普通饲喂。于饲养4周后每周选取5只实验组和3只对照组大鼠行肝脏MR、组织病理检查及测定脂肪含量,对mLIVE成像测得的2组大鼠肝脏脂肪分数(FF)与病理结果及肝脏脂肪含量进行比较。结果 对照组和实验组平均FF分别为(5.67±0.69)%和(10.48±3.24)%(P<0.05)。实验组11只轻度脂肪肝,16只中度脂肪肝,9只重度脂肪肝,平均FF分别为(7.99±1.48)%,(10.38±1.70)%和(13.71±4.33)%,两两比较差异均具有统计学意义(P<0.05)。2组大鼠肝脏平均脂肪含量分别为(18.83±6.29)nmol/mg和(50.44±20.24)nmol/mg(P<0.05),肝脏FF与脂肪含量呈显著正相关(r=0.74,P<0.001),直线回归方程为y=4.22+0.13x结论 mLIVE成像可定量分析非酒精性脂肪肝大鼠肝脏脂肪含量,可用于评估脂肪肝。
英文摘要:
      Objective To observe the value of MR multi-echo liver interpolated volume excitation image (mLIVE) in diagnosis of rat nonalcoholic fatty liver. Methods Totally 64 female SD rats were selected and randomly divided into experiment group (n=40) and control group (n=24). Rats in experimental group were fed high-fat diet, while those in control group were fed normal diet. Five experimental and 3 control rats were selected for liver MR examination, histopathological examination and liver fat content determination every week after 4 weeks, respectively. Then the results of live fat fraction (FF) obtained with mLIVE imaging, pathological and fat contents of the 2 groups were compared. Results The average FF value of control and experiment group was (5.67±0.69)% and (10.48±3.24)%, respectively (P<0.05).In experimental group, there were 11 rats with mild fatty liver, 16 with moderate fatty liver and 9 with severe fatty liver. The average FF value of different state of fatty liver in experiment group were (7.99±1.48)%, (10.38±1.70)% and (13.71±4.33)%, respectively (P<0.05). The average liver fat contents of 2 groups was (18.83±6.29)nmol/mg and (50.44±20.24)nmol/mg, respectively (P<0.05). There was positive correlation between liver FF and liver fat contents (r=0.74, P<0.001), and the linear regression equation was y=4.22+0.13x. Conclusion MR mLIVE imaging can be used for quantitative analysis of liver fat, and therefore the evaluation of fatty liver.
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