王佳,姚飞荣,胡竞成,毛青,付乃奇,李红,胡春洪.基于多回波肝脏内插容积激发成像评价大鼠非酒精性脂肪肝[J].中国医学影像技术,2020,36(1):27~31 |
基于多回波肝脏内插容积激发成像评价大鼠非酒精性脂肪肝 |
Evaluation of rat nonalcoholic fatty liver based on multi-echo liver interpolated volume excitation imaging |
投稿时间:2019-04-08 修订日期:2019-11-13 |
DOI:10.13929/j.issn.1003-3289.2020.01.007 |
中文关键词: 非酒精性脂肪肝 大鼠 磁共振成像 |
英文关键词:nonalcoholic fatty liver disease rat magnetic resonance imaging |
基金项目:江苏省数字创新诊疗装备应用示范研究项目(2017YFC0114300)。 |
|
摘要点击次数: 2187 |
全文下载次数: 785 |
中文摘要: |
目的 观察多回波肝脏内插容积激发成像(mLIVE)诊断非酒精性脂肪肝大鼠的价值。方法 选取64只雌性SD大鼠,随机分为实验组(n=40)及对照组(n=24),实验组喂饲高脂饮食、对照组给予普通饲喂。于饲养4周后每周选取5只实验组和3只对照组大鼠行肝脏MR、组织病理检查及测定脂肪含量,对mLIVE成像测得的2组大鼠肝脏脂肪分数(FF)与病理结果及肝脏脂肪含量进行比较。结果 对照组和实验组平均FF分别为(5.67±0.69)%和(10.48±3.24)%(P<0.05)。实验组11只轻度脂肪肝,16只中度脂肪肝,9只重度脂肪肝,平均FF分别为(7.99±1.48)%,(10.38±1.70)%和(13.71±4.33)%,两两比较差异均具有统计学意义(P<0.05)。2组大鼠肝脏平均脂肪含量分别为(18.83±6.29)nmol/mg和(50.44±20.24)nmol/mg(P<0.05),肝脏FF与脂肪含量呈显著正相关(r=0.74,P<0.001),直线回归方程为y=4.22+0.13x。结论 mLIVE成像可定量分析非酒精性脂肪肝大鼠肝脏脂肪含量,可用于评估脂肪肝。 |
英文摘要: |
Objective To observe the value of MR multi-echo liver interpolated volume excitation image (mLIVE) in diagnosis of rat nonalcoholic fatty liver. Methods Totally 64 female SD rats were selected and randomly divided into experiment group (n=40) and control group (n=24). Rats in experimental group were fed high-fat diet, while those in control group were fed normal diet. Five experimental and 3 control rats were selected for liver MR examination, histopathological examination and liver fat content determination every week after 4 weeks, respectively. Then the results of live fat fraction (FF) obtained with mLIVE imaging, pathological and fat contents of the 2 groups were compared. Results The average FF value of control and experiment group was (5.67±0.69)% and (10.48±3.24)%, respectively (P<0.05).In experimental group, there were 11 rats with mild fatty liver, 16 with moderate fatty liver and 9 with severe fatty liver. The average FF value of different state of fatty liver in experiment group were (7.99±1.48)%, (10.38±1.70)% and (13.71±4.33)%, respectively (P<0.05). The average liver fat contents of 2 groups was (18.83±6.29)nmol/mg and (50.44±20.24)nmol/mg, respectively (P<0.05). There was positive correlation between liver FF and liver fat contents (r=0.74, P<0.001), and the linear regression equation was y=4.22+0.13x. Conclusion MR mLIVE imaging can be used for quantitative analysis of liver fat, and therefore the evaluation of fatty liver. |
查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|