| 徐梦莹,李春花,李健,张攀,洪子涵,郑琳升,陈兵.b值1 000 s/mm2 DWI正常胎脑区域ADC值与孕龄的相关性分析[J].中国医学影像技术,2019,35(11):1707~1711 |
| b值1 000 s/mm2 DWI正常胎脑区域ADC值与孕龄的相关性分析 |
| Correlation between gestational age and ADC value in normal fetal brain region detected using DWI with b value as 1 000 s/mm2 |
| 投稿时间：2019-05-04 修订日期：2019-07-17 |
| DOI：10.13929/j.1003-3289.201905187 |
| 中文关键词: 胎儿 脑 扩散磁共振成像 b值 表观扩散系数 孕龄 |
| 英文关键词:fetus brain diffusion magnetic resonance imaging b value apparent diffusion coefficient gestational age |
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| 中文摘要: |
| 目的 探讨基于b值1 000 s/mm2 DWI生成的ADC图测得的正常胎脑区域ADC值与孕龄的关系。方法 回顾性分析因产前超声怀疑胎儿异常接受常规MR及DWI检查的106名孕妇的资料，其中孕中期（13~27周）28名、孕晚期（≥ 28周）78名。所有胎儿均经产前常规MR、DWI检查及出生后随访证实神经发育正常。行DWI检查时b值取1 000 s/mm2。基于DWI数据生成ADC图，并测量胎儿额叶、顶叶、颞叶、枕叶白质及基底核、丘脑、小脑半球、脑桥的ADC值。采用线性回归分析胎脑不同区域ADC值与孕龄的相关性。结果 正常胎脑不同部位ADC值从高至低依次为：顶叶白质[（1.84±0.08）mm2/s]、枕叶白质[（1.82±0.08）mm2/s]、额叶白质[（1.77±0.03）mm2/s]、颞叶白质[（1.70±0.13）mm2/s]、小脑半球[（1.41±0.10）mm2/s]、基底核[（1.40±0.13）mm2/s]、丘脑[（1.35±0.04）mm2/s]、脑桥[（1.27±0.08）mm2/s]。除额叶白质ADC值外，正常胎脑其余部位ADC值均与孕龄呈负相关（P均<0.05）。结论 正常胎脑区域ADC值大多遂随孕龄增加而减低，能够反映胎脑的发育过程。 |
| 英文摘要: |
| Objective To investigate the relationship between ADC value of normal fetal brain region obtained on ADC image generated with DWI of b value as 1000 s/mm2 and gestational age.Methods A retrospective analysis of 106 pregnant women who underwent routine MR and DWI examinations due to suspected fetal abnormalities with prenatal ultrasonography was performed. Among them, 28 pregnant women were in the second trimester (13-27 weeks) and 78 pregnant women were in the third trimester (≥ 28 weeks). All fetuses were confirmed as normal neurodevelopment with prenatal routine MR and DWI examinations, as while as postnatal follow-up. DWI was performed with b value of 1000 s/mm2. ADC maps were generated based on DWI,and ADC values of frontal lobe, parietal lobe, temporal lobe, occipital lobe white matters, basal nucleus, thalamus, cerebellar hemisphere and pons were measured. The correlation between ADC values in different fetal brain regions and gestational age was analyzed using linear regression.Results ADC values of different parts of normal fetal brain were in order from high to low:Parietal white matter ([1.84±0.08]mm2/s), occipital white matter ([1.82±0.08]mm2/s), frontal white matter ([1.77±0.03]mm2/s), temporal white matter ([1.70±0.13]mm2/s), cerebellar hemisphere ([1.41±0.10]mm2/s), basal ganglia ([1.40±0.13]mm2/s), thalamus ([1.35±0.04]mm2/s), pons ([1.27±0.08]mm2/s). Except for frontal white matter, ADC values of the rest of the normal fetal brain regions were negatively correlated with gestational age (all P<0.05).Conclusion Most of ADC values in normal fetal brain different regions decreased with increasing gestational age, which can reflect the developmental process of fetal brain. |
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