| 闫峰山,周晶,白岩,王梅云.不同Ki-67表达状态乳腺癌患者临床和DCE-MRI特征[J].中国医学影像技术,2019,35(11):1657~1662 |
| 不同Ki-67表达状态乳腺癌患者临床和DCE-MRI特征 |
| Clinical and DCE-MRI features of breast cancer in patients with different Ki-67 status |
| 投稿时间：2019-02-18 修订日期：2019-09-20 |
| DOI：10.13929/j.1003-3289.201902066 |
| 中文关键词: 乳腺肿瘤 磁共振成像 Ki-67 |
| 英文关键词:breast neoplasms magnetic resonance imaging Ki-67 |
| 基金项目:国家重点研发计划项目（2017YFE0103600）、国家自然科学基金（81720108021、81772009、81641168、31470047）、河南省科技攻关计划项目（182102310162）、中原千人计划-基础研究领军人才项目（ZYQR201810117）。 |
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| 中文摘要: |
| 目的 探讨乳腺癌临床和动态增强MRI（DCE-MRI）特征与肿瘤增殖抗原指数（Ki-67）表达之间的关系。方法 收集经手术病理证实的女性乳腺癌患者340例，术前均行乳腺DCE-MRI，术后进行Ki-67免疫组织化学检测，将其分为Ki-67低表达（Ki-67<14%）和高表达（Ki-67 ≥ 14%），比较患者临床特征（年龄、肿块大小、淋巴结转移状态、雌激素受体、孕激素受体、人表皮生长因子受体2）和肿瘤DCE-MRI特征（形态、边缘、T2WI信号、时间-信号强度曲线类型）。结果 Ki-67低表达和高表达患者中位年龄、淋巴结转移状态、肿块形态和T2WI信号差异无统计学意义（P=0.276、0.124、0.283、0.587），乳腺癌肿块最大径、组织学分级、雌激素受体、孕激素受体、人表皮生长因子受体2、边缘、强化类型和时间-信号强度曲线类型差异均有统计学意义（P均<0.05）。结论 不同Ki-67表达状态乳腺癌患者的基本临床特征和DCE-MRI影像征象存在一定的差异，有助于指导临床治疗决策和预后判断。 |
| 英文摘要: |
| Objective To investigate the relationship of clinical and dynamic enhanced MRI (DCE-MRI) characteristics of breast cancer in patients with different proliferative antigen index (Ki-67) status. Methods A total of 340 patients with breast cancer confirmed by surgical pathology were enrolled. All patients underwent breast DCE-MRI scanning before operation, and the pathological samples were stained with Ki-67 for immunohistochemistry. According to the status of Ki-67, the patients were divided into low-expression (Ki-6714%) group and high-expression (Ki-67 ≥ 14%) group. Clinical characteristics (patient's age, mass size, lymph node metastasis status, estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2) and DCE-MRI features (morphology, edge, T2WI signal, time-signal intensity curve type) were compared between Ki-67 low-expression and high-expression patients. Results In Ki-67 low-expression and the high-expression patients, there were not statistically significance in median age, lymph node metastasis status, morphology and T2WI signal (P=0.276, 0.124, 0.283, 0.587), there were significant differences in the mass size, histological grade, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, margin, enhancement type and time-signal intensity curve type (all P<0.05). Conclusion There are some differences in the clinical features and DCE-MRI imaging signs of breast cancer patients with different Ki-67 expression status, which is helpful to guide clinical treatment decision and estimate prognosis. |
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