| 黄俊浩,郭定波,欧芳元,易小琦,陈暇女,胡良波.单、双指数模型DWI鉴别肺部良恶性病变:Meta分析[J].中国医学影像技术,2019,35(9):1346~1351 |
| 单、双指数模型DWI鉴别肺部良恶性病变:Meta分析 |
| DWI based on monoexponential and biexponential models in differential diagnosis of benign and malignant lung lesions: Meta-analysis |
| 投稿时间：2019-02-15 修订日期：2019-07-16 |
| DOI：10.13929/j.1003-3289.201902049 |
| 中文关键词: 肺肿瘤 单指数模型 双指数模型 体素内不相干运动 扩散加权成像 综合分析 |
| 英文关键词:lung neoplasms monoexponential models biexponential models intravoxel incoherent motion diffusion weighted imaging meta-analysis |
| 基金项目:重庆市科委基础科学与前沿技术研究项目（cstc2016jcyjA0217）、重庆医科大学附属永川医院院内科研项目（YJLC201712）。 |
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| 中文摘要: |
| 目的 采用Meta分析评价单、双指数模型DWI鉴别诊断肺部良恶性病变的效能。方法 检索Embase、Pubmed、Cochrane Library、CNKI、万方和维普数据库建库至2018年12月，单指数及双指数模型DWI诊断肺部良恶性病变相关文献，筛选符合纳入标准者进行质量评价，采用Meta-Disc 1.4及Stata 15.0软件进行统计分析。结果 共纳入10篇文献（中、英文文献各5篇）、672例患者（695个病灶）。ADC值、D值诊断肺部良恶性病变的敏感度分别约0.78[95% CI（0.73，0.83）]、0.90[95% CI（0.87，0.93）），特异度分别约0.71[95% CI（0.64，0.78）]、0.64[95% CI（0.57，0.70）]，诊断比值比分别为12.59[95% CI（4.93，32.11）]、19.58[95% CI（7.06，54.29）]，汇总受试者工作特征曲线AUC分别为0.848 9、0.885 1。结论 ADC值、D值鉴别肺良恶性病变均有高诊断效能，D值诊断效能优于ADC值。 |
| 英文摘要: |
| Objective To evaluate the diagnostic efficacy of DWI based on monoexponential and biexponential models in differential diagnosis of benign and malignant lung lesions. Methods Studies related to diagnosis of benign and malignant lung lesions by DWI based on monoexponential and biexponential models were retrieved from Embase, Pubmed, Cochrane Library, CNKI, Wanfang Med Online and VIP databases which were performed up to December, 2018. The studies that meet the inclusion criteria were evaluated with quality assessment of diagnostic accuracy studies. Meta-Disc version 1.4 and STATA 15.0 software were used for statistics analysis. Results Totally 10 studies (5 English, 5 Chinese), including a total of 695 lesions in 672 patients were enrolled. The sensitivity of ADC value and D value in differential diagnosis of benign and malignant lung lesions was 0.78 (95%CI[0.73, 0.83]), 0.90 (95%CI[0.87, 0.93]), specificity was 0.71 (95%CI[0.64, 0.78]), 0.64 (95%CI[0.57, 0.70]), the diagnostic odds ratio was 12.59 (95%CI[4.93, 32.11]), 19.58 (95%CI[7.06, 54.29]), and the AUC of summary ROC curve was 0.848 9, 0.885 1, respectively. Conclusion ADC value and D value both have good diagnostic efficacy in distinguishing benign and malignant lung lesions, and the diagnostic efficacy of D value is better than ADC value. |
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