| 康钰,洪楠,吴冰.多发性硬化的非均匀磁化传递成像研究[J].中国医学影像技术,2019,35(7):981~984 |
| 多发性硬化的非均匀磁化传递成像研究 |
| Study of inhomogeneous magnetization transfer imaging in multiple sclerosis |
| 投稿时间：2019-01-13 修订日期：2019-05-04 |
| DOI：10.13929/j.1003-3289.201901082 |
| 中文关键词: 多发性硬化 非均匀磁化传递成像 磁共振成像 |
| 英文关键词:multiple sclerosis inhomogeneous magnetization transfer imaging magnetic resonance imaging |
| 基金项目: |
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| 摘要点击次数: 1897 |
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| 中文摘要: |
| 目的 评价非均匀磁化传递（ihMT）成像诊断多发性硬化（MS）的价值。方法 对18例临床诊断为MS的患者及16名健康志愿者行ihMT成像，测量并比较MS患者白质内病灶与健康志愿者白质区磁化传递率（MTR）、量化磁化传递值（qMT）、非均匀磁化传递率（ihMTR）和非均匀量化磁化传递值（qihMT）的差异，并采用Spearman相关分析评价MS患者ihMT成像参数与临床扩展致残量表评分（EDSS）的相关性。结果 MS病灶的MTR、qMT、ihMTR、qihMT均低于健康志愿者脑白质（P均<0.001）；MTR、qMT与EDSS呈中等负相关（r=-0.440、-0.572，P=0.004、0.002），ihMTR、qihMT与EDSS呈强负相关（r=-0.704、-0.739，P均<0.001）。结论 ihMTR和qihMT值能准确反映白质髓鞘含量的变化，且与MS临床症状相关性好，具有较好的临床应用前景。 |
| 英文摘要: |
| Objective To observe the value of inhomogeneous magnetization transfer (ihMT) imaging in diagnosis of multiple sclerosis (MS). Methods Totally 18 patients with clinical diagnosed MS and 16 healthy volunteers were enrolled. ihMT imagings were obtained, while magnetic transfer ratio (MTR), quantitative magnetization transfer (qMT) value, inhomogeneous magnetization transfer ratio (ihMTR) and inhomogeneous quantitative magnetization transfer (qihMT) value of MS lesions and normal white mater of volunteers were measured, respectively. ihMT metrics were compared between MS patients and volunteers. Spearman correlation was conducted to analyze the correlation of MTR, qMT, ihMTR and qihMT values and clinical expanded disability status scale (EDSS) for MS patients. Results MTR, qMT, ihMTR and qihMT of MS patients were significantly lower than those of volunteers (all P<0.001). There was moderate negative correlation between MTR, qMT and EDSS (r=-0.440, -0.572, P=0.004, 0.002), also significant negative correlation between ihMTR, qihMT and EDSS (r=-0.704, -0.739, both P<0.001). Conclusion ihMTR and qihMT values are sensitive to detect the changes of myelin content and have good correlation with clinical symptoms, therefore having good prospects for clinical application. |
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