| 陈永露,谢新凤,梅颖洁,杨粤龙,吴晓玲,刘红军,黄飚.酰胺质子转移加权成像评估高级别胶质瘤异柠檬酸脱氢酶基因状态[J].中国医学影像技术,2019,35(6):823~827 |
| 酰胺质子转移加权成像评估高级别胶质瘤异柠檬酸脱氢酶基因状态 |
| Amide proton transfer weighted imaging evaluation on isocitrate dehydrogenase mutation status in patients with high-grade gliomas |
| 投稿时间：2018-10-27 修订日期：2019-03-21 |
| DOI：10.13929/j.1003-3289.201810156 |
| 中文关键词: 神经胶质瘤 酰胺质子转移加权成像 异柠檬酸脱氢酶 突变 |
| 英文关键词:glioma amide proton transfer weighted imaging isocitrate dehydrogenase mutation |
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| 摘要点击次数: 2042 |
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| 中文摘要: |
| 目的 探讨酰胺质子转移加权（APTw）成像预测高级别胶质瘤异柠檬酸脱氢酶（IDH）野生型和突变型的价值。方法 收集经病理证实的25例高级别胶质瘤患者，术前均行头颅MR平扫、T1WI增强及APTw扫描。依据术后病理分为IDH野生型组和IDH突变型组，依据FLAIR图像选取肿瘤实性成分，逐层测量肿瘤APT值，取其平均值。采用独立样本t检验分析组间APT值的差异，ROC曲线评估APT值判断IDH基因状态的效能。结果 25例高级别胶质瘤中，IDH突变型9例，IDH野生型16例。IDH野生型组APT值[（3.21±0.82）%]明显高于IDH突变型组[（2.23±0.72）%；t=2.89，P<0.05]，其判断IDH基因状态的AUC为0.84（P<0.05），诊断IDH野生型的敏感度为93.8%，特异度为66.7%。结论 APTw成像可用于预测高级别胶质瘤中IDH基因状态。 |
| 英文摘要: |
| Objective To observe the value of amide proton transfer weighted (APTw) imaging in predicting isocitrate dehydrogenase (IDH) wild type and IDH mutant of high-grade gliomas. Methods Twenty-five patients with pathologically confirmed high-grade gliomas were enrolled. All patients underwent preoperative MR scanning, including routine sequences, T1WI enhancement and APTw scanning. According to the pathology, the patients were divided into IDH wild type group and IDH mutant group. ROIs were placed on FLAIR images of all tumor layers to select the solid components of the tumor, and APT values of each layer were obtained to get the mean value. Differences of APT values were analyzed between groups using independent sample t test, and ROC curve analysis was performed to evaluate the diagnostic efficacy of APT values in assessing the gene status of IDH. Results Among 25 patients of high-grade gliomas, 9 cases were IDH mutant and 16 cases were IDH wild type. APT value of IDH wild type group ([3.21±0.82]%) was significantly higher than that of IDH mutant group ([2.23±0.72]%; t=2.89, P<0.05), and the AUC was 0.84 (P<0.05). The sensitivity and specificity of IDH wild type diagnosis was 93.8% and 66.7%, respectively. Conclusion APTw imaging can be used to predict gene status of IDH in high-grade gliomas. |
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