| 宋双双,卢洁.脑胶质瘤MGMT启动子甲基化影像学研究进展[J].中国医学影像技术,2019,35(5):782~785 |
| 脑胶质瘤MGMT启动子甲基化影像学研究进展 |
| Progresses in imaging study of MGMT promoter methylation in gliomas |
| 投稿时间：2018-11-02 修订日期：2019-03-18 |
| DOI：10.13929/j.1003-3289.201811009 |
| 中文关键词: 神经胶质瘤 O6-甲基鸟嘌呤DNA甲基转移酶 磁共振成像 影像组学 |
| 英文关键词:glioma O6-methylguanine-DNA methyltransferase magnetic resonance imaging radiomics |
| 基金项目:北京市医院管理局"登峰"计划专项经费（DFL20180802）。 |
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| 摘要点击次数: 1992 |
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| 中文摘要: |
| O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化是脑胶质瘤的重要分子生物学标志物，与脑胶质瘤的发生、诊断及预后关系密切。MRI、PET等影像学检查及影像组学方法能够获得反映脑胶质瘤结构、功能、代谢甚至分子水平改变的重要信息，有望于术前无创、准确预测MGMT启动子甲基化状态。本文就脑胶质瘤影像学特征与MGMT启动子甲基化关系的研究进展进行综述。 |
| 英文摘要: |
| O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is an important molecular biomarker which plays a key role in tumor development and determine the molecular subtypes and prognosis of gliomas. Radiomics and imaging examinations like MR and PET can obtain information of morphology, function, metabolism and molecular alterations of gliomas, which may help comprehensively and non-invasively predict MGMT promoter methylation status in gliomas. The relationships between imaging features and MGMT promoter methylation status of gliomas were reviewed in this article. |
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