| 徐磊,孟庆乐,杨瑞,钱鑫宇,王峰,蒋红兵.基于不同能量窗和准直器的177Lu-Dotatate SPECT/CT定量采集条件[J].中国医学影像技术,2019,35(5):759~764 |
| 基于不同能量窗和准直器的177Lu-Dotatate SPECT/CT定量采集条件 |
| Acquisition protocols of quantitative 177Lu-Dotatate SPECT/CT imaging based on different energy windows and collimators |
| 投稿时间：2018-11-06 修订日期：2019-01-31 |
| DOI：10.13929/j.1003-3289.201811034 |
| 中文关键词: 镥 奥曲肽 体层摄影术,发射型计算机,单光子 体层摄影术,X线计算机 采集条件 |
| 英文关键词:Lutetium octreotide tomography, emission-computed, single-photon tomography, X-ray computed acquisition protocol |
| 基金项目:江苏省重点研发专项基金项目（BE2017612）、南京市医学科技发展资金"青年工程"人才培养专项经费资助项目（QRX11033）、南京医科大学科技发展基金面上项目（2017NJMU127）。 |
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| 中文摘要: |
| 目的 探讨基于不同能量窗和准直器的177Lu-Dotatate SPECT/CT定量采集条件。方法 以微球和背景放射性浓度比为12∶1的国际电工委员会体模为实验对象。采用低能高分辨率（LEHR）、中能通用（MEGP）和高能通用（HEGP）3种类型准直器采集SPECT图像，主能窗为113 keV、208 keV和113 keV+208 keV，能宽均为20%，散射线采用CT衰减校正和三能窗法校正，形成9种采集条件：LEHR_113、LEHR_208、LEHR_113+208、MEGP_113、MEGP_208、MEGP_113+208、HEGP_113、HEGP_208和HEGP_113+208。定量分析9种采集条件下采用部分容积校正后的微球与背景放射性浓度比值、相对误差和转换系数。结果 LEHR_208对应SPECT图像对比度最差，MEGP_208和MEGP_113+208对应图像视觉分辨率最佳。9种采集条件所得放射性浓度平均比值均低于真实值（F=2.659，P=0.040）。MEGP_113+208所得放射性浓度比值相对误差最小[（－1.33±6.40）%]，LEHR_208的相对误差最大[（－58.34±14.42）%]。不同采集条件所得放射性转换系数差异有统计学意义（F=4.846，P=0.003）。结论 不同采集条件对177Lu-Dotatate SPECT/CT定量显像结果影响显著，MEGP准直器联合113 keV+208 keV能窗所得图像质量最佳，放射性浓度比值最接近真实值。 |
| 英文摘要: |
| Objective To explore the optimal acquisition protocols for 177Lu-Dotatate SPECT/CT imaging based on different energy windows and collimators. Methods 177Lu SPECT images of a NEMA IEC body phantom with known activity concentration ration (12:1) between filled hollow spheres and uniform background were acquired with 3 different collimators:Low energy high resolution (LEHR), medium energy general purpose (MEGP) and high energy general purpose (HEGP). Main energy window was defined around the energy peak 113 keV, 208 keV and 113 keV+208 keV with 20% width. Scatter correction was performed with applying attenuation correction and triple energy window method. Thus 9 different acquisition protocols could be produced, including LEHR_113, LEHR_208, LEHR_113+208, MEGP_113, MEGP_208, MEGP_113+208, HEGP_113, HEGP_208 and HEGP_113+208 in short. The intensity ratio between spheres and background, relative error and conversion factor were measured and corrected for partial volume effect and used to compare the performance of different methods. Results The contrast of MEGP_208 SPECT image was the worst, whereas better visual resolution images were achieved by MEGP_208 and MEGP_113+208. The measured average intensity ratios of 9 methods were all lower than the real ratio (F=2.659, P=0.040). The relative error of intensity ratio in MEGP_113+208 was the minimum ([-1.33±6.40]%), and in LEHR_208 was the maximum ([-58.34±14.42]%). All acquisition protocols showed significant difference in conversion factor (F=4.846, P=0.003).Conclusion Different acquisition protocols have significant effect on the results of 177Lu-Dotatate SPECT/CT quantitative imaging. Image quality of MEGP collimator combined with 113 keV+208 keV is the best, and the intensity ratio is the closest to the real ratio. |
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