| 张卫林,曹礼庭,蒋冰蕾,熊云涛.CEUS参数评估兔骨骼肌缺血再灌注后肌肉活力[J].中国医学影像技术,2019,35(5):646~650 |
| CEUS参数评估兔骨骼肌缺血再灌注后肌肉活力 |
| CEUS parameters in evaluation of muscle viability after ischemia-reperfusion in rabbit skeletal muscles |
| 投稿时间：2018-09-17 修订日期：2019-03-25 |
| DOI：10.13929/j.1003-3289.201809094 |
| 中文关键词: 肌,骨骼 再灌注损伤 缺血 超声检查 造影剂 |
| 英文关键词:muscle, skeletal reperfusion injury ischemia ultrasonography contrast media |
| 基金项目:四川省卫生厅科研课题（120429）。 |
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| 中文摘要: |
| 目的 探讨CEUS参数评估兔骨骼肌缺血再灌注后肌肉活力的可行性。方法 建立兔骨骼肌缺血再灌注损伤（SMIRI）模型。根据损伤最严重区域肌肉"4C"征，将其分为有肌肉活力组（n=10）和无肌肉活力组（n=8）。对比2组造模前（T0）及去掉橡胶圈（再灌注）即刻（T1）、1 h（T2）、2 h（T3）、4 h（T4）时患侧小腿损伤最严重区域CEUS参数。采用ROC曲线分析各参数对骨骼肌缺血再灌注后肌肉活力的诊断效能。结果 有肌肉活力组T1及T4时绝对峰值强度（API）均大于无肌肉活力组（P均<0.05），其余指标同一时间点2组间比较差异均无统计学意义（P均>0.05）。ROC曲线结果显示，T1时API（截断值为6.93 dB）评估骨骼肌缺血再灌注后肌肉活力的敏感度为100%，特异度为60%，AUC为0.85[95%CI（0.67，1.00，P<0.05）]；T4时API（截断值为4.25 dB）的敏感度为100%，特异度为70%，AUC为0.89[95%CI（0.75，1.00，P<0.05）]。结论 CEUS参数可反映骨骼肌缺血再灌注后肌肉活力，其中API可作为评价缺血再灌注后肌肉活力的指标。 |
| 英文摘要: |
| Objective To investigate the feasibility of CEUS parameters in evaluation of muscle viability after ischemia-reperfusion in rabbit skeletal muscles. Methods Ischemia-reperfusion injury models of skeletal muscles (SMIRI) were established in rabbits. According to the "4C" sign of muscles in the most severely damaged area, the rabbits were then divided into muscle vitality group (n=10) and non-muscle vitality group (n=8). CEUS parameters of the most severely damaged area of the affected leg were compared between 2 groups before modeling (T0) and immediately (T1), 1 h (T2), 2 h (T3), 4 h (T4) after the rubber rings were removed. ROC curves were used to evaluate the diagnostic efficiency of CEUS parameters on viability of skeletal muscles after ischemia-reperfusion. Results Absolute peak intensity (API) of T1 and T4 in muscle vitality group was higher than those in no-muscle vitality group (both P<0.05), there were no significant differences in other indexes between 2 groups at each time point (all P>0.05). ROC curves results showed that the sensitivity and specificity of API on T1 (cut-off value 6.93 dB) for evaluating muscle viability after ischemia-reperfusion of skeletal muscles was 100% and 60%, AUC was 0.85 (95%CI[0.67, 1.00], P<0.05), while API on T4 (cut-off value 4.25 dB) were 100% and 70%, AUC was 0.89 (95%CI[0.75, 1.00], P<0.05), respectively. Conclusion CEUS parameters can reflect muscle viability after ischemia-reperfusion of skeletal muscles, and API can be used as an evaluation index in ischemia-reperfusion injury rabbit models. |
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